1H-Pyrrolo[2,3-d]pyrimidine, 4,6-dichloro-2-methyl-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-d]pyrimidine, 4,6-dichloro-2-methyl-
• CAS No.: 22277-09-4
• Molecular Formula: C₇H₅Cl₂N₃
• Molecular Weight: 202.043
• Mol file: 22277-09-4.mol

Synonyms:2-Methyl-4,6-dichlor-7H-pyrrolo<2,3-d>pyrimidin;4,6-dichloro-2-methylpyrrolo

Chemical Property of 1H-Pyrrolo[2,3-d]pyrimidine, 4,6-dichloro-2-methyl-

Chemical Property:

• PSA: 41.57000
• LogP: 2.57310

Purity/Quality:

4,6-dichloro-2-methyl-7H-Pyrrolo[2,3-d]pyrimidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-d]pyrimidine, 4,6-dichloro-2-methyl-

There total 3 articles about 1H-Pyrrolo[2,3-d]pyrimidine, 4,6-dichloro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione (858276-03-6) → 4,6-dichloro-2-methylpyrrolo<2,3-d>pyrimidine (22277-09-4)

Guidance literature:

With trichlorophosphate;

Reference yield:

diethyl 2-cyanosuccinate (10359-15-6) → 4,6-dichloro-2-methylpyrrolo<2,3-d>pyrimidine (22277-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanolic HCl / beim Behandeln des Reaktionsgemisches mit Acetamidin-hydrochlorid und aethanol. Natriumaethylat

2: water; NaOH

3: POCl₃

With hydrogenchloride; sodium hydroxide; water; trichlorophosphate;

Reference yield:

(4-amino-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid (858269-56-4) → 4,6-dichloro-2-methylpyrrolo<2,3-d>pyrimidine (22277-09-4)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

(4-amino-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid

2-methyl-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione

diethyl 2-cyanosuccinate

Downstream raw materials:

4,6-dichloro-2-methyl-7-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo<2,3-d>pyrimidine

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