1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one

Base Information

• Chemical Name: 1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one
• CAS No.: 22317-35-7
• Molecular Formula: C16H16O5
• Molecular Weight: 288.3
• DSSTox Substance ID: DTXSID40511347
• Nikkaji Number: J728.160I
• Wikidata: Q82370097
• Mol file: 22317-35-7.mol

Synonyms:22317-35-7;DTXSID40511347;1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one;1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethanone

Chemical Property of 1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one

Chemical Property:

• Melting Point: 94–95°C
• PSA: 64.99000
• LogP: 2.67110
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 288.09977361
• Heavy Atom Count: 21
• Complexity: 333

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCC(=O)C2=CC(=C(C=C2)O)OC

Technology Process of 1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one

There total 14 articles about 1-(4-Hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethanol (7382-68-5) → 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one (22317-35-7)

Guidance literature:

With N-hydroxyphthalimide; oxygen; 4,4′-bis(diphenylamino)benzophenone; In acetone; at 20 ℃; for 24h; under 760.051 Torr; Irradiation;

DOI:10.1021/acs.joc.6b01704

Reference yield: 79.1%

α-bromo-3-methoxy-4-hydroxyacetophenone (69638-06-8) + 2-methoxy-phenol (90-05-1) → 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one (22317-35-7)

Guidance literature:

2-methoxy-phenol; With sodium ethanolate; sodium; In ethanol; at 70 ℃; for 1h; Sealed tube;

α-bromo-3-methoxy-4-hydroxyacetophenone; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Temperature;

Reference yield: 34.0%

1-(4-benzoyloxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethanone (1252675-90-3) → 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one (22317-35-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

DOI:10.1039/c2dt31065a

upstream raw materials:

α-bromo-3-methoxy-4-hydroxyacetophenone

2-methoxy-phenol

1-(3-methoxy-4-hydroxyphenyl)ethanone

1-(4-benzoyloxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethanone

Downstream raw materials:

1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1-propanone

β-hydroxy-α-(2-methoxyphenoxy)4-hydroxy-3-methoxypropiophenone

2-methoxy-4-n-propylphenol

4-Ethylguaiacol