[1,2,4]triazolo[4,3-a]pyridin-3-amine

Base Information

• Chemical Name: [1,2,4]triazolo[4,3-a]pyridin-3-amine
• CAS No.: 767-62-4
• Molecular Formula: C6H6N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• Mol file: 767-62-4.mol

Synonyms:s-Triazolo[4,3-a]pyridine,3-amino- (7CI,8CI);NSC 76010;(1,2,4)Triazolo(4,3-a)pyridin-3(2H)-imine;{s-Triazolo[4,3-a]pyridine,} 3-amino-;1,2,4-Triazolo[4, 3-a]pyridin-3-amine;

Chemical Property of [1,2,4]triazolo[4,3-a]pyridin-3-amine

Chemical Property:

• Melting Point: 226-232°C
• Refractive Index: 1.773
• PKA: 5.75±0.50(Predicted)
• PSA: 56.21000
• Density: 1.5 g/cm³
• LogP: 0.89270

Purity/Quality:

98%,99%, ^*data from raw suppliers

[1,2,4]triazolo[4,3-a]pyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,2,4]triazolo[4,3-a]pyridin-3-amine

There total 3 articles about [1,2,4]triazolo[4,3-a]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

pyrid-2-ylhydrazine (4930-98-7) + di(1H-imidazol-1-yl)methanimine (104619-51-4) → 3-amino-s-triazolo-<4,3-a>-pyridne (767-62-4)

Guidance literature:

In tetrahydrofuran; Reflux;

Reference yield:

pyrid-2-ylhydrazine (4930-98-7) + bromocyane (506-68-3) → 3-amino-s-triazolo-<4,3-a>-pyridne (767-62-4)

Guidance literature:

Reference yield:

→ 3-amino-s-triazolo-<4,3-a>-pyridne (767-62-4)

Guidance literature:

2-Hydrazino-pyridin, Cyanogenbromid, MeOH;

DOI:10.1021/jo01339a057

upstream raw materials:

pyrid-2-ylhydrazine

bromocyane

di(1H-imidazol-1-yl)methanimine

Downstream raw materials:

3-Chlor-s-triazolo<4,3-a>pyridin

N-(2,3-dimethoxybenzyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

N-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetamide

Refernces

• 1、 Wu, Yong-Qian,Limburg, David C.,Wilkinson, Douglas E.,Hamilton, Gregory S.. "Formation of nitrogen-containing heterocycles using di(imidazole-1-yl)methanimine". . p. 191 - 193. Retrieved 2007/10/03.