(S)-3-Hydroxy-2-Methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-3-Hydroxy-2-Methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester
• CAS No.: 223678-66-8
• Molecular Formula: C10H15NO4
• Molecular Weight: 213.23000
• Hs Code.: 2933990090
• Mol file: 223678-66-8.mol

Synonyms:(S)-tert-Butyl 3-hydroxy-2-methyl-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate;(S)-3-Hydroxy-2-methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-Butyl ester;

Chemical Property of (S)-3-Hydroxy-2-Methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 66.84000
• LogP: 1.53200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Hydroxy-2-methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Hydroxy-2-Methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

There total 7 articles about (S)-3-Hydroxy-2-Methyl-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

cycl-isopropylidene malonate (2033-24-1) + L-N-Boc-Ala (15761-38-3) → 5(S)-N-tert-butoxycarbonyl-4-hydroxy-5-methyl-3-pyrrolin-2-one (223678-66-8)

Guidance literature:

cycl-isopropylidene malonate; L-N-Boc-Ala; With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃;

With ethyl acetate; In dichloromethane; for 0.5h; Reflux;

DOI:10.1021/ol1024663

Reference yield:

C10H17NO5 → 5(S)-N-tert-butoxycarbonyl-4-hydroxy-5-methyl-3-pyrrolin-2-one (223678-66-8)

Guidance literature:

With dmap; In dichloromethane; ethyl acetate; for 0.5h; Heating / reflux;

Reference yield:

L-N-Boc-Ala (15761-38-3) → 5(S)-N-tert-butoxycarbonyl-4-hydroxy-5-methyl-3-pyrrolin-2-one (223678-66-8)

Guidance literature:

L-N-Boc-Ala; polymer supported Meldrum's acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Heating;

DOI:10.1016/S0960-894X(03)00502-X

upstream raw materials:

tert-butyl N-[(1S)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-hydroxy-1-methylethyl]carbamate

L-N-Boc-Ala

cycl-isopropylidene malonate

Downstream raw materials:

C₃₀H₃₀NO₅P

(+)-(5S)-N-tert-butoxycarbonyl-3-[(E)-1'-hydroxy-3'-phenylallylidene]-5-methylpyrrolidine-2,4-dione

(S)-5-benzyl-4-(tert-butoxy)-1-((S)-1-((S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one

(5S)-5-methyl-2,4-dioxopyrrolidine