2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl-
CAS No.:224157-49-7
Molecular Formula:C31H40N2O6Si
Molecular Weight:564.754
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth
yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl-

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl-

There total 2 articles about 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-5-[(1R,3E)-1,6-dihydroxy-3-hexenyl]-4-[[(1,1-dimethyleth yl)diphenylsilyl]oxy]tetrahydro-2-furanyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 224177-27-9
5'-<3'-(2''-hydroxyethyl)-4'-trimethylsilyl-2'-oxacyclopentyl>-4-t-butyldiphenylsilyl-oxy-2-thyminyl-1-oxacyclopentane

: 224157-49-7
3'-O-tert-butyldiphenylsilyl-5'-C(R)-(5''-hydroxy-2''-pentenyl)thymidine

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1002/1099-0690(200112)2001:24<4693::AID-EJOC4693>3.0.CO;2-J

Reference yield: 7.0%

: 116264-65-4
ω-tertbutyldimethyl-silyloxyallyltrimethylsilane

: 146604-43-5
1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil

: 224157-49-7
3'-O-tert-butyldiphenylsilyl-5'-C(R)-(5''-hydroxy-2''-pentenyl)thymidine

: 224177-27-9
5'-<3'-(2''-hydroxyethyl)-4'-trimethylsilyl-2'-oxacyclopentyl>-4-t-butyldiphenylsilyl-oxy-2-thyminyl-1-oxacyclopentane

: 5'-<(5''-trimethylsilyl-2''-oxacyclopentyl)>methyl-3'-O-(t-butyldiphenylsilyl)-thymidine

: 3'-O-(t-butyldiphenylsilyl)-5'-C-(3-(3-t-butyldimethylsilyloxy-2-trimethylsilyl)-2-oxetanyl)-thymidine

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; Further byproducts given; 1.) -78 deg C, 3 h, 2.) -78 deg C -> room temperature;
DOI:10.1016/S0040-4020(99)00246-X

Reference yield: 64.0%

: 224157-49-7
3'-O-tert-butyldiphenylsilyl-5'-C(R)-(5''-hydroxy-2''-pentenyl)thymidine

: 927687-31-8
3'-O-tert-butyldiphenylsilyl-5'-C(R)-(2''-hydroxyethyl)thymidine

Guidance literature:: 3'-O-tert-butyldiphenylsilyl-5'-C(R)-(5''-hydroxy-2''-pentenyl)thymidine; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; for 16h;

With sodium periodate; In methanol; at 0 - 20 ℃; for 3h;

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 12h; Further stages.;
DOI:10.1002/ejoc.200600593