2'-Methoxy-3-phenylpropiophenone

Base Information

• Chemical Name: 2'-Methoxy-3-phenylpropiophenone
• CAS No.: 22618-13-9
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID80443456
• Nikkaji Number: J1.559.330J
• Mol file: 22618-13-9.mol

Synonyms:2'-METHOXY-3-PHENYLPROPIOPHENONE;22618-13-9;1-(2-METHOXYPHENYL)-3-PHENYLPROPAN-1-ONE;MFCD03842916;SCHEMBL6203601;DTXSID80443456;AKOS010013901;1-(2-Methoxyphenyl)-3-phenyl-1-propanone

Chemical Property of 2'-Methoxy-3-phenylpropiophenone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 387.431oC at 760 mmHg
• Flash Point: 172.062oC
• PSA: 26.30000
• Density: 1.082g/cm3
• LogP: 3.51070
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 240.115029749
• Heavy Atom Count: 18
• Complexity: 256

Purity/Quality:

97% ^*data from raw suppliers

2'-Methoxy-3-phenylpropiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2

Technology Process of 2'-Methoxy-3-phenylpropiophenone

There total 15 articles about 2'-Methoxy-3-phenylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(E)-1-(2-methoxyphenyl)-3-phenylprop-2-en-1-one (6948-61-4,58202-23-6,40524-62-7) → 1-(2-methoxyphenyl)-3-phenylpropan-1-one (22618-13-9)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel; In benzene; at 70 ℃; for 18h;

DOI:10.1246/bcsj.60.4019

Reference yield: 86.0%

2-Methoxyacetophenone (579-74-8) + benzyl alcohol (100-51-6,185532-71-2) → 1-(2-methoxyphenyl)-3-phenylpropan-1-one (22618-13-9)

Guidance literature:

With 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride; potassium hydroxide; In toluene; at 110 ℃; for 5h;

DOI:10.1002/hlca.201400076

Reference yield: 86.0%

(E)-3-phenylpropenal (14371-10-9) + 2-Methoxyphenylboronic acid (5720-06-9) → 1-(2-methoxyphenyl)-3-phenylpropan-1-one (22618-13-9)

Guidance literature:

With rhodium(II) acetate dimer; water; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; at 90 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1039/c8ob01997e

upstream raw materials:

(E)-1-(2-methoxyphenyl)-3-phenylprop-2-en-1-one

1-phenyl-2-bromoethane

2-Methoxybenzoyl chloride

(E)-3-phenylpropenal

Downstream raw materials:

2-benzyl-1-(2-methoxyphenyl)-3-phenylpropan-1-one

trans-3-Phenyl-1-(2-hydroxy-phenyl)-propen-1

1-(2-hydroxyphenyl)-3-phenyl-1-propanol

1-Acetoxy-1-<2-methoxy-benzoyl>-2-phenyl-aethan

Refernces

• 1、 Liu, Haiwang,Xue, Fei,Wang, Mu,Tang, Xinxin,Wu, Jie. "Neutral-eosin Y-catalyzed regioselective hydroacylation of aryl alkenes under visible-light irradiation". supporting information. p. 406 - 410. Retrieved 2020/12/30.
• 2、 -. "Preparation method of novel aromatic ketone compound". Paragraph 0047-0048. . Retrieved 2020/12/08.