1H-Indole-1-acetic acid, 5-nitro-

Base Information

• Chemical Name: 1H-Indole-1-acetic acid, 5-nitro-
• CAS No.: 226901-50-4
• Molecular Formula: C10H8N2O4
• Molecular Weight: 220.18200
• Mol file: 226901-50-4.mol

Synonyms:5-nitroindoleacetic acid;1H-Indole-1-acetic acid,5-nitro;1-carboxymethyl-5-nitroindole;

Chemical Property of 1H-Indole-1-acetic acid, 5-nitro-

Chemical Property:

• Boiling Point: 479.6±25.0 °C(Predicted)
• PSA: 88.05000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 2.15730

Purity/Quality:

99% ^*data from raw suppliers

2-(5-Nitro-1H-indol-1-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1-acetic acid, 5-nitro-

There total 2 articles about 1H-Indole-1-acetic acid, 5-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-(5-nitro-1H-indol-1-yl)acetate (250647-55-3) → (5-nitro-1H-indol-1-yl)acetic acid (226901-50-4)

Guidance literature:

With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm500857r

Reference yield:

5-nitroindole (6146-52-7) → (5-nitro-1H-indol-1-yl)acetic acid (226901-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 67.5 percent / NaH / dimethylformamide / 16 h / 20 °C

2: 84.2 percent / aq. NaOH / methanol / 16 h / 20 °C

With sodium hydroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ol990270q

Reference yield:

(5-nitro-1H-indol-1-yl)acetic acid (226901-50-4) → (S)-N-{[5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl]acetyl}-L-leucine (1623002-61-8)

Guidance literature:

Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 2828.7 Torr / Inert atmosphere

3: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: dichloromethane / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;

DOI:10.1021/jm500857r

upstream raw materials:

methyl 2-(5-nitro-1H-indol-1-yl)acetate

5-nitroindole

Downstream raw materials:

(S)-N-{[5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl]acetyl}-L-leucine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 226901-50-4 1H-Indole-1-acetic acid, 5-nitro-

Send

Send

Metric Ton KG G Pound L ML

Send

Send