Technology Process of 4 O-daunosaminyl-2,4,5,12-tetrahydroxy-2-nonanoyl-1,2,3,4-tetrahydro-6,11-naphthacenedione
There total 7 articles about 4 O-daunosaminyl-2,4,5,12-tetrahydroxy-2-nonanoyl-1,2,3,4-tetrahydro-6,11-naphthacenedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium hydroxide;
Yield given. Multistep reaction;
1.) THF, 40 min, r.t.; 2.) MeOH, Et2O;
DOI:10.1248/cpb.34.4605
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 1.) trimethylsilyl trifluoromethanesulfonate / 1.) CH2Cl2, 0 deg C, 0.5 h; 2.) r.t., 15 h
3: 1.) bromine; 2.) 10percent NaOH; 3.) concd. HCl / 1.) CCl4, H2O, 2h 45 min, reflux, irradiation; 2.) H2O, 40 min; 3.) THF, r.t., 15 h
5: 1.) 0.1 M sodium hydroxide; 2.) 0.25 M HCl / 1.) THF, 40 min, r.t.; 2.) MeOH, Et2O
With
hydrogenchloride; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; bromine;
DOI:10.1248/cpb.34.4605
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 1.) trimethylsilyl trifluoromethanesulfonate / 1.) CH2Cl2, 0 deg C, 0.5 h; 2.) r.t., 15 h
3: 1.) bromine; 2.) 10percent NaOH; 3.) concd. HCl / 1.) CCl4, H2O, 2h 45 min, reflux, irradiation; 2.) H2O, 40 min; 3.) THF, r.t., 15 h
5: 1.) 0.1 M sodium hydroxide; 2.) 0.25 M HCl / 1.) THF, 40 min, r.t.; 2.) MeOH, Et2O
With
hydrogenchloride; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; bromine;
DOI:10.1248/cpb.34.4605
