1H-Pyrazole, 3,5-dimethyl-4-(phenylmethyl)-

Base Information

• Chemical Name: 1H-Pyrazole, 3,5-dimethyl-4-(phenylmethyl)-
• CAS No.: 23147-77-5
• Molecular Formula: C12H14N2
• Molecular Weight: 186.257
• Hs Code.: 2933199090
• Mol file: 23147-77-5.mol

Synonyms:3,5-Dimethyl-4-benzylpyrazole;4-benzyl-3,5-dimethylpyrazole;3,5-Dimethyl-4-phenyl-pyrazol;4-Benzyl-3,5-dimethyl-pyrazol;3,5-Dimethyl-4-benzyl-pyrazol;

Chemical Property of 1H-Pyrazole, 3,5-dimethyl-4-(phenylmethyl)-

Chemical Property:

• Melting Point: 147-148℃
• PSA: 28.68000
• Density: 1.077
• LogP: 2.61730

Purity/Quality:

97% ^*data from raw suppliers

4-benzyl-3,5-dimethyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole, 3,5-dimethyl-4-(phenylmethyl)-

There total 9 articles about 1H-Pyrazole, 3,5-dimethyl-4-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-benzyl-pentane-2,4-dione (1134-87-8) → 4-benzyl-3,5-dimethyl-1H-pyrazole (23147-77-5)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1039/c0nj00774a

Reference yield: 67.0%

3-Benzyl-3,5-dimethyl-3H-pyrazole (75326-07-7) → 1-benzyl-3,5-dimethyl-1H-pyrazole (1134-81-2) + 4-benzyl-3,5-dimethyl-1H-pyrazole (23147-77-5)

Guidance literature:

In dimethyl sulfoxide; at 120 ℃;

DOI:10.1016/S0040-4039(00)92734-5

Reference yield: 32.0%

sodium acetylacetonate (15435-71-9,1118-67-8) + benzyl chloride (100-44-7) → 4-benzyl-3,5-dimethyl-1H-pyrazole (23147-77-5)

Guidance literature:

sodium acetylacetonate; benzyl chloride; In N,N-dimethyl-formamide; at 80 ℃;

With hydrazine hydrate; In ethanol; for 5h; Further stages.; Heating;

DOI:10.1021/ja010426t

upstream raw materials:

morpholine

C₂₁H₁₈N₂O₂

3-Benzyl-3,5-dimethyl-3H-pyrazole

3-benzyl-pentane-2,4-dione

Downstream raw materials:

benzoic acid