2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy-

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy-
• CAS No.: 23204-42-4
• Molecular Formula: C13H12O5
• Molecular Weight: 248.235
• DSSTox Substance ID: DTXSID00446146
• Nikkaji Number: J898.263E
• Wikidata: Q82264732
• Mol file: 23204-42-4.mol

Synonyms:2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy-;23204-42-4;DTXSID00446146;5,7-Dimethoxy-6-hydroxy-2-naphthoic acid;6-hydroxy-5,7-dimethoxy-2-naphthoic acid

Chemical Property of 2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy-

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 248.06847348
• Heavy Atom Count: 18
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C2C=CC(=CC2=C1)C(=O)O)OC)O

Technology Process of 2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy-

There total 3 articles about 2-Naphthalenecarboxylic acid, 6-hydroxy-5,7-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trans-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxy-1,2-dihydronaphthalene-2,3-dicarboxylic acid (26350-60-7,52802-10-5) → 2,6-dimethoxy-p-quinone (530-55-2,26547-64-8) + 6-hydroxy-5,7-dimethoxynaphthalene-2-carboxylic acid (23204-42-4)

Guidance literature:

With air; In water; pH 13;

DOI:10.1016/S0040-4039(97)01775-9

Reference yield: 72.0%

trans-3,5-dimethoxy-4-hydroxycinnamic acid (530-59-6,7362-37-0) → 2,6-dimethoxy-p-quinone (530-55-2,26547-64-8) + 6-hydroxy-5,7-dimethoxynaphthalene-2-carboxylic acid (23204-42-4)

Guidance literature:

With air; In water;

DOI:10.1016/S0040-4039(97)01775-9

Reference yield: 60.0%

(1RS,2SR)-1,2-dihydro-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxynaphthalene-2,3-dicarboxylic acid dimethyl ester → 6-hydroxy-5,7-dimethoxynaphthalene-2-carboxylic acid (23204-42-4) + trans-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxy-1,2-dihydronaphthalene-2,3-dicarboxylic acid (26350-60-7,52802-10-5)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 16h;

DOI:10.1021/jf020910v

upstream raw materials:

trans-3,5-dimethoxy-4-hydroxycinnamic acid

trans-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxy-1,2-dihydronaphthalene-2,3-dicarboxylic acid

Downstream raw materials:

6-Acetoxy-5,7-dimethoxy-2-naphthoesaeure

5,6,7-Trimethoxy-2-naphthoesaeure-methylester