[2,2'-Bipyridine]-5,5'-diol

Base Information

• Chemical Name: [2,2'-Bipyridine]-5,5'-diol
• CAS No.: 2326-78-5
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.18300
• Mol file: 2326-78-5.mol

Synonyms:5,5'-dihydroxy-2,2'-bipyridyl;5,5'-Dihydroxy-2,2'-bipyridin;4,4'-Dihydroxy-2,2`-bipyridine;[2,2'-Bipyridine]-5,5'-diol;[2,2']Bipyridinyl-5,5'-diol;

Chemical Property of [2,2'-Bipyridine]-5,5'-diol

Chemical Property:

• Melting Point: 250 °C
• Boiling Point: 561.0±45.0 °C(Predicted)
• PKA: 4.03±0.20(Predicted)
• PSA: 66.24000
• Density: 1.363±0.06 g/cm3(Predicted)
• LogP: 1.55480

Purity/Quality:

99%, ^*data from raw suppliers

2,2''-Bipyridine-5,5''-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2,2'-Bipyridine]-5,5'-diol

There total 3 articles about [2,2'-Bipyridine]-5,5'-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5,5′-dimethoxy-2,2′-bipyridine (39858-87-2) → 5,5'-dihydroxy-2,2'-bipyridyl (2326-78-5)

Guidance literature:

With acetic acid; for 37h; Heating;

DOI:10.1021/jm000107x

Reference yield:

2-bromo-5-methoxypyridine (105170-27-2) → 5,5'-dihydroxy-2,2'-bipyridyl (2326-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Zn; bis(triphenylphosphine)nickel(II); tetraethylammonium iodide / tetrahydrofuran / 8 h / 50 °C

2: 84 percent / 47percent HBr; AcOH / 37 h / Heating

With Ni(PPh₃)2; tetraethylammonium iodide; acetic acid; zinc; In tetrahydrofuran;

DOI:10.1021/jm000107x

Reference yield:

→ 5,5'-dihydroxy-2,2'-bipyridyl (2326-78-5)

Guidance literature:

Disulfonsaeure, KOH/Δ;

upstream raw materials:

5,5′-dimethoxy-2,2′-bipyridine

2-bromo-5-methoxypyridine

Refernces

• 1、 Fukuda,Seto,Furuta,Ebisu,Oomori,Terashima. "Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker". . p. 1396 - 1406. Retrieved 2007/10/03.