6-(4-Methylpiperazin-1-yl)phenanthridine

Base Information

Chemical Name:6-(4-Methylpiperazin-1-yl)phenanthridine
CAS No.:23441-13-6
Molecular Formula:C18H19N3
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID50433889
Nikkaji Number:J1.109.451A
Wikidata:Q82248158
ChEMBL ID:CHEMBL43193

Synonyms:6-(4-methylpiperazin-1-yl)phenanthridine;23441-13-6;CHEMBL43193;6-(4-Methyl-piperazin-1-yl)-phenanthridine;6-[4-Methylpiperazin-1-yl]phenanthridine;D04AXY;DTXSID50433889;6-(4-Methylpiperazino)phenanthridine;BDBM50063258;PD182754

Suppliers and Price of 6-(4-Methylpiperazin-1-yl)phenanthridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6-(4-Methylpiperazin-1-yl)phenanthridine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:277.157897619
Heavy Atom Count:21
Complexity:350

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC3=CC=CC=C3C4=CC=CC=C42

Technology Process of 6-(4-Methylpiperazin-1-yl)phenanthridine

There total 8 articles about 6-(4-Methylpiperazin-1-yl)phenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-01-3
1-methyl-piperazine

: 400820-15-7
2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

: 23441-13-6
6-(4-methyl-piperazyl)-phenanthridine

Guidance literature:: 1-methyl-piperazine; With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 0.166667h;

2'-fluoro-[1,1'-biphenyl]-2-carbonitrile; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/ol0170051

Reference yield: 86.0%

: 109-01-3
1-methyl-piperazine

: 15679-03-5
6-chlorophenanthridine

: 23441-13-6
6-(4-methyl-piperazyl)-phenanthridine

Guidance literature:: at 130 - 140 ℃; for 24h;
DOI:10.1021/jm970645i

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 23441-13-6
6-(4-methyl-piperazyl)-phenanthridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / K₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 7 h / 85 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -10 °C

2.2: 98 percent / tetrahydrofuran; hexane / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; ethanol; hexane; toluene;
DOI:10.1021/ol0170051