Imidazo[2,1-a]isoquinoline

Base Information

• Chemical Name: Imidazo[2,1-a]isoquinoline
• CAS No.: 234-70-8
• Molecular Formula: C11H8N2
• Molecular Weight: 168.198
• Mol file: 234-70-8.mol

Synonyms:imidazo[2,1-a]isoquinoline;Imidazo<2,1-a>isochinolin;Imidazo<2,1-a>isoquinolin;Imidazo<1,2-a>isochinolin;

Chemical Property of Imidazo[2,1-a]isoquinoline

Chemical Property:

• PSA: 17.30000
• LogP: 2.48750

Purity/Quality:

99% ^*data from raw suppliers

Imidazo[2,1-a]isoquinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[2,1-a]isoquinoline

There total 15 articles about Imidazo[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-bromo-ethyl)-isoquinolinium bromide → 2-methylbenzo[4,5]imidazo[2,1-a]isoquinoline (234-70-8)

Guidance literature:

With manganese(IV) oxide; ammonia; sodium carbonate; In toluene; Heating;

DOI:10.1021/ol070263z

Reference yield: 96.0%

(Z)-1-(2-phenyl-1-ethenyl)-1H-imidazole → 2-methylbenzo[4,5]imidazo[2,1-a]isoquinoline (234-70-8)

Guidance literature:

With copper diacetate; acetic acid; palladium dichloride; In para-xylene; at 140 ℃; for 24h;

DOI:10.1002/adsc.201100801

Reference yield: 86.0%

isoquinolin-1-ylamine (1532-84-9) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-methylbenzo[4,5]imidazo[2,1-a]isoquinoline (234-70-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; for 22h; Heating;

DOI:10.1246/bcsj.72.1327

upstream raw materials:

isoquinolin-1-ylamine

Bromoacetaldehyde diethyl acetal

isoquinoline

(Z)-β-bromostyrene

Downstream raw materials:

1-benzyl-1H-imidazo[2,1-a]isoquinolin-4-ium bromide