1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one

Base Information

• Chemical Name: 1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one
• CAS No.: 23489-30-7
• Molecular Formula: C₂₈H₂₁O₂P
• Molecular Weight: 420.447
• DSSTox Substance ID: DTXSID80535466
• Wikidata: Q82409776
• Mol file: 23489-30-7.mol

Synonyms:23489-30-7;1-(Benzofuran-2-yl)-2-(triphenylphosphoranylidene)ethanone;DTXSID80535466;1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one

Chemical Property of 1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one

Chemical Property:

• XLogP3: 6.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 420.12791691
• Heavy Atom Count: 31
• Complexity: 600

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=CC(=O)C2=CC3=CC=CC=C3O2)(C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of 1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one

There total 2 articles about 1-(1-Benzofuran-2-yl)-2-(triphenyl-lambda~5~-phosphanylidene)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzofuran-2-yl)-2-bromoethan-1-one (23489-36-3) + triphenylphosphine (603-35-0) → 1-benzofuran-2-yl-2-(triphenyl-λ5-phosphanylidene)-ethanone (23489-30-7)

Guidance literature:

1-(benzofuran-2-yl)-2-bromoethan-1-one; triphenylphosphine; In toluene; at 20 ℃; for 2h;

With water; sodium hydroxide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jacs.1c04334

Reference yield:

1-(benzo[b]furan-2-yl)ethanone (1646-26-0) → 1-benzofuran-2-yl-2-(triphenyl-λ5-phosphanylidene)-ethanone (23489-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; toluene-4-sulfonic acid / ethyl acetate / 12 h / 20 °C

2.1: toluene / 2 h / 20 °C

2.2: 2 h / 20 °C

With N-Bromosuccinimide; toluene-4-sulfonic acid; In ethyl acetate; toluene;

DOI:10.1021/jacs.1c04334

Reference yield: 35.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1-benzofuran-2-yl-2-(triphenyl-λ5-phosphanylidene)-ethanone (23489-30-7) → 1-(1-benzofuran-2-yl)-4-phenylbutan-1-one

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate; thiophenol; In dichloromethane; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1039/c8sc04195d

upstream raw materials:

1-(benzo[b]furan-2-yl)ethanone

1-(benzofuran-2-yl)-2-bromoethan-1-one

triphenylphosphine