5-Acetyl-2-chlorobenzene-1-sulfonamide

Base Information

• Chemical Name: 5-Acetyl-2-chlorobenzene-1-sulfonamide
• CAS No.: 2350-44-9
• Molecular Formula: C8H8ClNO3S
• Molecular Weight: 233.675
• DSSTox Substance ID: DTXSID101294611
• Mol file: 2350-44-9.mol

Synonyms:5-acetyl-2-chlorobenzene-1-sulfonamide;2350-44-9;5-acetyl-2-chlorobenzenesulfonamide;SCHEMBL7143525;BCZGXDORRDXENN-UHFFFAOYSA-N;DTXSID101294611;4'-chloro-3'-sulfamoylacetophenone;5-acetyl 2-chlorobenzenesulfonamide;CAA35044;5-acetyl-2-chlorobenzenesulphonamide;5-acetyl-2-chloro-benzenesulphonamide;AKOS013153499;EN300-107856;Z1160860116

Chemical Property of 5-Acetyl-2-chlorobenzene-1-sulfonamide

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 232.9913420
• Heavy Atom Count: 14
• Complexity: 322

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC(=C(C=C1)Cl)S(=O)(=O)N

Technology Process of 5-Acetyl-2-chlorobenzene-1-sulfonamide

There total 3 articles about 5-Acetyl-2-chlorobenzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-chloro-3'-chlorosulfonylacetophenone (3511-47-5) → 4'-chloro-3'-sulfamoyl-acetophenone (2350-44-9)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1248/cpb.30.4092

Reference yield:

3-amino-4-chloroacetophenone (79406-57-8) → 4'-chloro-3'-sulfamoyl-acetophenone (2350-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNO₂, cc HCl 2.) CuCl₂*2H₂O, SO₂ / 1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C

2: cc NH₄OH / tetrahydrofuran / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sulfur dioxide; sodium nitrite; In tetrahydrofuran;

DOI:10.1248/cpb.30.4092

Reference yield:

→ 4'-chloro-3'-sulfamoyl-acetophenone (2350-44-9)

Guidance literature:

5-Acetyl-2-chlor-benzolsulfonylchlorid, 28percentig. wss. NH4OH;

upstream raw materials:

4'-chloro-3'-chlorosulfonylacetophenone

3-amino-4-chloroacetophenone

Downstream raw materials:

2-bromo-4'-chloro-3'-sulfamoyl-acetophenone

5-Acetyl-2-[N-methyl-N-(phenylmethyl)amino]benzenesulphonamide

5-acetyl-2-dimethylaminobenzenesulphonamide

4'-chloro-3'-methoxycarbonylsulfamoyl-acetophenone