3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1)

Base Information

• Chemical Name: 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1)
• CAS No.: 236406-47-6
• Molecular Formula: C14H26N2O2.ClH
• Molecular Weight: 290.834
• Hs Code.: 2933990090
• Mol file: 236406-47-6.mol

Synonyms:

Chemical Property of 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1)

Chemical Property:

• PSA: 41.57000
• LogP: 3.45580

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl3,9-diazaspiro[5.5]undecane-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1)

There total 6 articles about 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 9-benzyl-3,9-diazaspiro[5.5]undecane-3-carboxylate (929302-01-2) → 3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester hydrochloride (236406-47-6)

Guidance literature:

tert-butyl 9-benzyl-3,9-diazaspiro[5.5]undecane-3-carboxylate; With hydrogen; palladium dihydroxide; In methanol; at 35 ℃; under 2844.39 Torr;

With hydrogenchloride; In methanol; diethyl ether; pH=6 - 7;

Reference yield:

ethyl 2-[1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-piperidyl]acetate (160133-32-4) → 3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester hydrochloride (236406-47-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / -40 - 20 °C

3: dmap; triethylamine / dichloromethane / 0.5 h / -25 °C

4: ethanol / 20 h / Reflux

5: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 40 °C / 3102.97 Torr

With dmap; lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

diethyl 2,2'-(1-(tert-butoxycarbonyl)piperidine-4,4-diyl)diacetate (1051383-60-8) → 3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester hydrochloride (236406-47-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / -40 - 20 °C

2: dmap; triethylamine / dichloromethane / 0.5 h / -25 °C

3: ethanol / 20 h / Reflux

4: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 40 °C / 3102.97 Torr

With dmap; lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

upstream raw materials:

tert-butyl 9-benzyl-3,9-diazaspiro[5.5]undecane-3-carboxylate

ethyl 2-[1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-piperidyl]acetate

diethyl 2,2'-(1-(tert-butoxycarbonyl)piperidine-4,4-diyl)diacetate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 9-(3-phenoxybenzyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate

tert-butyl 9-[2-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

tert-butyl-9-(2-phenoxybenzyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate

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