Leptomerine

Base Information

• Chemical Name: Leptomerine
• CAS No.: 22048-97-1
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Mol file: 22048-97-1.mol

Synonyms:4(1H)-Quinolone,1-methyl-2-propyl- (7CI,8CI); Leptomerine

Chemical Property of Leptomerine

Chemical Property:

• Boiling Point: 300.4±42.0 °C(Predicted)
• PKA: 2.56±0.70(Predicted)
• PSA: 22.00000
• Density: 1.063±0.06 g/cm3(Predicted)
• LogP: 2.49100

Purity/Quality:

98.5% ^*data from raw suppliers

Leptomerine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Leptomerine

There total 5 articles about Leptomerine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-butylthio-1-methyl-2-propylquinolinium trifluoromethanesulfonate → leptomerine (22048-97-1)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

DOI:10.3987/COM-92-S(T)98

Reference yield:

aniline (62-53-3) → leptomerine (22048-97-1)

Guidance literature:

Multi-step reaction with 4 steps

1: MgSO₄ / toluene / 0 °C

2: 70 percent / BF₃*OEt₂, air / toluene / Ambient temperature

3: 95 percent / 1 h / 60 °C

4: 70 percent / 1 N NaOH / methanol / 2 h / Heating

With sodium hydroxide; air; boron trifluoride diethyl etherate; magnesium sulfate; In methanol; toluene;

DOI:10.3987/COM-92-S(T)98

Reference yield:

But-(E)-ylidene-phenyl-amine → leptomerine (22048-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / BF₃*OEt₂, air / toluene / Ambient temperature

2: 95 percent / 1 h / 60 °C

3: 70 percent / 1 N NaOH / methanol / 2 h / Heating

With sodium hydroxide; air; boron trifluoride diethyl etherate; In methanol; toluene;

DOI:10.3987/COM-92-S(T)98

upstream raw materials:

aniline

4-butylthio-2-propylquinoline

Refernces