1-ChloroMethyl-4-Methanesulfonyl-benzene

Base Information

• Chemical Name: 1-ChloroMethyl-4-Methanesulfonyl-benzene
• CAS No.: 2389-73-3
• Molecular Formula: C7H6Cl2O2S
• Molecular Weight: 225.095
• Hs Code.: 2904909090
• Mol file: 2389-73-3.mol

Synonyms:p-chloromethylbenzenesulfonyl chloride;4-Chloromethylbenzenesulfonyl chloride;4-chloromethyl-benzene-1-sulfonyl chloride;4-Chlormethyl-benzolsulfonylchlorid;11-Chlor-toluol-sulfonsaeure-(4)-chlorid;Benzenesulfonyl chloride,4-(chloromethyl);

Chemical Property of 1-ChloroMethyl-4-Methanesulfonyl-benzene

Chemical Property:

• Melting Point: 64-65 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 183-185 °C(Press: 15 Torr)
• PSA: 42.52000
• Density: 1.463±0.06 g/cm3(Predicted)
• LogP: 3.43370

Purity/Quality:

99% ^*data from raw suppliers

4-(Chloromethyl)-benzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Chloromethyl)-benzenesulfonyl Chloride is used to synthesize sulfur substituted phenyldifluoromethylphosphonic acids as PTP-1B inhibitors.

Technology Process of 1-ChloroMethyl-4-Methanesulfonyl-benzene

There total 1 articles about 1-ChloroMethyl-4-Methanesulfonyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-chloromethylbenzenesulfonyl chloride (2389-73-3)

Guidance literature:

With tetrachloromethane; sulfuryl dichloride; dibenzoyl peroxide;

Reference yield: 75.0%

4-chloromethylbenzenesulfonyl chloride (2389-73-3) + 2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silapentadecan-15-amine → 4-(chloromethyl)-N-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silapentadecan-15-yl)benzenesulfonamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c9cc09427j

Reference yield: 53.0%

3-(2-aminoethyl)-5-methoxy-2-methylindolyl 4-chlorophenyl ketone hydrochloride + 4-chloromethylbenzenesulfonyl chloride (2389-73-3) → 3-[2-({[4-(chloromethyl)phenyl]sulfonyl}amino)ethyl]-5-methoxy-2-methylindolyl 4-chlorophenyl ketone

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0611861

upstream raw materials:

p-toluenesulfonyl chloride

Downstream raw materials:

p-tosyl chloride

1-(2-Chloro-ethanesulfonyl)-4-chloromethyl-benzene

4-homosulfanilamide

1-Chloromethyl-4-ethenesulfonyl-benzene

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