6-Methoxypyrazine-2-carboxylic acid

Base Information

• Chemical Name: 6-Methoxypyrazine-2-carboxylic acid
• CAS No.: 24005-61-6
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.125
• Hs Code.: 2933990090
• European Community (EC) Number: 803-493-8
• DSSTox Substance ID: DTXSID00355941
• Wikidata: Q72485694
• ChEMBL ID: CHEMBL5206653
• Mol file: 24005-61-6.mol

Synonyms:6-methoxypyrazine-2-carboxylic acid;24005-61-6;6-Methoxy-2-pyrazinecarboxylic acid;6-Methoxy-pyrazinecarboxylicacid;Pyrazinecarboxylic acid, 6-methoxy-;MFCD00233277;6-METHOXY-2-PYRAZINECARBOXYLICACID;SCHEMBL1760361;CHEMBL5206653;DTXSID00355941;RWGSCFHUIFPLEI-UHFFFAOYSA-N;AKOS005264679;AB05020;CS-W022507;AS-30778;SY004494;2-METHOXYPYRAZINE-6-CARBOXYLIC ACID;BB 0260729;FT-0621199;A19747;EN300-172870;AF-615/25002831;Z1198152489

Chemical Property of 6-Methoxypyrazine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.000189mmHg at 25°C
• Melting Point: 176-181°C
• Boiling Point: 315.1oC at 760 mmHg
• PKA: 2.79±0.10(Predicted)
• Flash Point: 144.3oC
• PSA: 72.31000
• Density: 1.371g/cm3
• LogP: 0.18340
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 154.03784206
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxypyrazine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=CN=C1)C(=O)O

Technology Process of 6-Methoxypyrazine-2-carboxylic acid

There total 1 articles about 6-Methoxypyrazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-methoxypyrazine-2-carboxylic acid (24005-61-6)

Guidance literature:

6-Methoxy-pyrazin-2-carbamidsaeuremethylester (I), NaOH/W.;

Reference yield:

6-methoxypyrazine-2-carboxylic acid (24005-61-6) → C25H27N3O5*ClH

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / acetonitrile / 60 °C / Inert atmosphere

2: acetonitrile / 24 h / 20 °C / Inert atmosphere

3: acetyl chloride / methanol / Inert atmosphere

With thionyl chloride; acetyl chloride; In methanol; acetonitrile;

DOI:10.1080/14756366.2020.1747449

Reference yield:

6-methoxypyrazine-2-carboxylic acid (24005-61-6) → N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-6-methoxypyrazine-2-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / acetonitrile / 60 °C / Inert atmosphere

2: acetonitrile / 24 h / 20 °C / Inert atmosphere

With thionyl chloride; In acetonitrile;

DOI:10.1080/14756366.2020.1747449

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