4-Hydroxyoctadecanoic acid methyl ester

Base Information

• Chemical Name: 4-Hydroxyoctadecanoic acid methyl ester
• CAS No.: 2420-38-4
• Molecular Formula: C19H38O3
• Molecular Weight: 314.50300
• Hs Code.: 2918199090
• Mol file: 2420-38-4.mol

Synonyms:Methyl-4-hydroxystearat;Octadecanoic acid,4-hydroxy-,methyl ester;4-hydroxy-octadecanoic acid methyl ester;DL-4-Hydroxy-octadecansaeure-methylester;4-Hydroxy-octadecansaeuremethylester;

Chemical Property of 4-Hydroxyoctadecanoic acid methyl ester

Chemical Property:

• Boiling Point: 413.7±28.0 °C(Predicted)
• PKA: 14.70±0.20(Predicted)
• PSA: 46.53000
• Density: 0.915±0.06 g/cm3(Predicted)
• LogP: 5.39170

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxyoctadecanoic acid methyl ester

There total 6 articles about 4-Hydroxyoctadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 4-oxooctadecanoate (2380-19-0) → methyl 4-hydroxyoctadecanoate (2420-38-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h; cooling;

DOI:10.1021/ja002462i

Reference yield:

tetradecylmagnesium bromide (88303-25-7) → methyl 4-hydroxyoctadecanoate (2420-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.33 h / 0 °C

1.2: 94 percent / tetrahydrofuran / 0.75 h / 0 °C

2.1: 97 percent / NaBH₄ / methanol / 0.5 h / cooling

With sodium tetrahydroborate; copper(l) iodide; In tetrahydrofuran; methanol;

DOI:10.1021/ja002462i

Reference yield:

succinic acid monomethylester chloride (1490-25-1) → methyl 4-hydroxyoctadecanoate (2420-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.33 h / 0 °C

1.2: 94 percent / tetrahydrofuran / 0.75 h / 0 °C

2.1: 97 percent / NaBH₄ / methanol / 0.5 h / cooling

With sodium tetrahydroborate; copper(l) iodide; In tetrahydrofuran; methanol;

DOI:10.1021/ja002462i

upstream raw materials:

methyl 4-oxooctadecanoate

tetradecylmagnesium bromide

succinic acid monomethylester chloride

4-oxooctadecanoic acid

Downstream raw materials:

methyl 4-(4-vinylphenoxy)octadecanoate

Refernces