4,5-DIHYDRO-2H-BENZO[G]INDAZOLE

Base Information

• Chemical Name: 4,5-DIHYDRO-2H-BENZO[G]INDAZOLE
• CAS No.: 24445-06-5
• Molecular Formula: C11H10N2
• Molecular Weight: 170.21000
• Mol file: 24445-06-5.mol

Synonyms:4,5-dihydro-1(2)H-benzo[g]indazole;4,5-Dihydro-1(2)H-benz[g]indazol;

Chemical Property of 4,5-DIHYDRO-2H-BENZO[G]INDAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 2.17530

Purity/Quality:

99% ^*data from raw suppliers

4,5-dihydro-1H-Benz[g]indazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIHYDRO-2H-BENZO[G]INDAZOLE

There total 7 articles about 4,5-DIHYDRO-2H-BENZO[G]INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride (187964-68-7) + N-[3,4-dihydro-1(2H)-naphthalenylidene]-1-propanamine → 4,5-dihydro-1H-benzo[g]indazole (24445-06-5)

Guidance literature:

N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride; N-[3,4-dihydro-1(2H)-naphthalenylidene]-1-propanamine; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrazine hydrate; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1002/jhet.5570370548

Reference yield:

2-hydroxymethylene-3,4-dihydro-2H-naphthalen-1-one (87937-55-1) → 4,5-dihydro-1H-benzo[g]indazole (24445-06-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Yield given; Heating;

DOI:10.1021/jm00133a025

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 4,5-dihydro-1H-benzo[g]indazole (24445-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃ONa / pyridine / 18 h / Ambient temperature

2: hydrazine hydrate / ethanol / 6 h / Heating

With sodium methylate; hydrazine hydrate; In pyridine; ethanol;

DOI:10.1021/jm00133a025

upstream raw materials:

1,2,3,4-tetrahydro-2-(hydroxymethylene)naphthalen-1-one

2-hydroxymethylene-3,4-dihydro-2H-naphthalen-1-one

N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride

3,4-dihydronaphthalene-1(2H)-one

Refernces

• 1、 Katritzky,Denisenko,Denisenko,Arend. "Convenient one-pot syntheses of pyrazoles from imines, a vilsmeier type reagent and hydrazine". . p. 1309 - 1314. Retrieved 2007/10/03.