HOECHST 34580

Base Information

• Chemical Name: HOECHST 34580
• CAS No.: 23555-00-2
• Molecular Formula: C27H29 N7
• Molecular Weight: 451.574
• Mol file: 23555-00-2.mol

Synonyms:2,5'-Bibenzimidazole,2'-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)- (8CI); HOE 34580;Hoechst 34580; Proamine

Chemical Property of HOECHST 34580

Chemical Property:

• Melting Point: >300℃
• PKA: 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃)
• PSA: 82.54000
• LogP: 5.86710
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Soluble in dimethyl sulfoxide, water

Purity/Quality:

99%+, ^*data from raw suppliers

Hoechst 34580 Trihydrochloride salt, ≥98.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HOECHST 34580

There total 8 articles about HOECHST 34580 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-dimethylamino-1-[5'-imino(ethoxy)methylbenzimidazo-2'-yl]benzene hydrochloride (696581-55-2) + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → N,N-dimethyl-4-[5-(4-methyl-piperazin-1-yl)-1(3)H,1'(3')H-[2,5']bibenzoimidazolyl-2'-yl]-aniline (23555-00-2)

Guidance literature:

4-dimethylamino-1-[5'-imino(ethoxy)methylbenzimidazo-2'-yl]benzene hydrochloride; 4-(4-methylpiperazino)-1,2-diaminobenzene; With acetic acid; In ethanol; for 1.5h; Heating / reflux;

With ammonia; In water;

Reference yield: 82.0%

ethyl 2-(4-dimethylaminophenyl)-1H-benzimidazole-5-carboximidate hydrochloride + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → 4-dimethylamino-1-<5'-<5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl>benzimidazol-2'-yl>benzene (23555-00-2)

Guidance literature:

With acetic acid; In ethanol; for 1.5h; Heating;

Reference yield: 42.0%

4-dimethylamino-benzaldehyde (100-10-7) + 2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline (23491-49-8) → 4-dimethylamino-1-<5'-<5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl>benzimidazol-2'-yl>benzene (23555-00-2)

Guidance literature:

With acetic acid; In ethanol; Heating;

upstream raw materials:

4-dimethylamino-1-[5'-imino(ethoxy)methylbenzimidazo-2'-yl]benzene hydrochloride

4-(4-methylpiperazino)-1,2-diaminobenzene

4-dimethylamino-benzaldehyde

2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline

Refernces

• 1、 Kelly, David P.,Bateman, Stuart A.,Hook, Robert J.,Martin, Roger F.,Reum, Monica E.,et al.. "DNA Binding Compounds. VI. Synthesis and Characterization of 2,5'-Disubstituted Bibenzimidazoles Related to the DNA Minor Groove Hoechst 33258". . p. 1751 - 1770. Retrieved 2007/10/02.