5H-Pyrrolo[2,1-a]isoindole

Base Information

• Chemical Name: 5H-Pyrrolo[2,1-a]isoindole
• CAS No.: 247-54-1
• Molecular Formula: C11H9N
• Molecular Weight: 155.199
• Mol file: 247-54-1.mol

Synonyms:

Chemical Property of 5H-Pyrrolo[2,1-a]isoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-Pyrrolo[2,1-a]isoindole

There total 7 articles about 5H-Pyrrolo[2,1-a]isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(2-bromobenzyl)-1H-pyrrole-2-carbaldehyde (156210-54-7) → 5H-pyrrolo-<2,1-a>isoindole (247-54-1) + 1-benzyl-2-methylsulfonylpyrrole (156210-75-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 24h; Heating; Irradiation;

Reference yield: 63.0%

1-(2-iodobenzyl)-1H-pyrrole + 3-(5-bromo-pent-1-ynyl)-benzoic acid ethyl ester (1042073-69-7) → C25H23NO2 (1169944-55-1) + 5H-pyrrolo-<2,1-a>isoindole (247-54-1)

Guidance literature:

With trifuran-2-yl-phosphane; norbornene; caesium carbonate; palladium dichloride; In acetonitrile; at 20 - 90 ℃; Inert atmosphere; sealed tube;

DOI:10.1055/s-0028-1088195

Reference yield: 60.0%

1-(2-iodobenzyl)-1H-pyrrole + 1-(5-bromo-pent-1-ynyl)-2-methoxybenzene (1042073-62-0) → C23H21NO (1169944-54-0) + 5H-pyrrolo-<2,1-a>isoindole (247-54-1)

Guidance literature:

With trifuran-2-yl-phosphane; norbornene; caesium carbonate; palladium dichloride; In acetonitrile; at 20 - 90 ℃; Inert atmosphere; sealed tube;

DOI:10.1055/s-0028-1088195

upstream raw materials:

1-(2-bromobenzyl)-1H-pyrrole-2-carbaldehyde

1-(2-bromobenzyl)-2-methylsufonylpyrrole

1-(5-bromo-pent-1-ynyl)-4-methylbenzene

1-(5-bromopent-1-yn-1-yl)-4-nitrobenzene