2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-3-(methylamino)-

Base Information

Chemical Name:2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-3-(methylamino)-
CAS No.:248247-37-2
Molecular Formula:C18H24N2O
Molecular Weight:284.401
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-3-(methylamino)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-3-(methylamino)-

There total 8 articles about 2(1H)-Pyridinone, 4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-3-(methylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 311319-90-1
N-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide

: 248247-37-2
4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-3-methylamino-1H-pyridin-2-one

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm0009437

Reference yield:

: 197229-98-4
5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

: 248247-37-2
4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-3-methylamino-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: Cu^II dimethylsulfide complex / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.3: 37 percent / tetrahydrofuran; hexane / 12 h / 20 °C

2.1: 100 percent / aq. HCl / 3.5 h / Heating

3.1: 66 percent / formic acid / 3 h / Heating

4.1: 57 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; formic acid; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: complexation / 1.3: Alkylation / 2.1: Hydrolysis / 3.1: Formylation / 4.1: Reduction;
DOI:10.1021/jm0009437

Reference yield:

: 5779-95-3
3,5-dimethylbenzaldehyde

: 248247-37-2
4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-3-methylamino-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 71 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 95 percent / pyridine / 84 h / 60 °C

3.1: 99 percent / H₂; AcOH / 30percent Pd/C / H₂O; dioxane / 24 h / 20 °C / 7600.51 Torr

4.1: 100 percent / aq. HCl / 3.5 h / Heating

5.1: 66 percent / formic acid / 3 h / Heating

6.1: 57 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; formic acid; N,N,N,N,-tetramethylethylenediamine; hydrogen; acetic acid; 30percent Pd/C; In tetrahydrofuran; 1,4-dioxane; hexane; water; 1.1: Metallation / 1.2: Addition / 2.1: Acetylation / 3.1: Catalytic hydrogenation / 4.1: Hydrolysis / 5.1: Formylation / 6.1: Reduction;
DOI:10.1021/jm0009437