Boronic acid, [2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)thio]phenyl]-

Base Information

Chemical Name:Boronic acid, [2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)thio]phenyl]-
CAS No.:248270-00-0
Molecular Formula:C9H9BF4O2S
Molecular Weight:268.04
Hs Code.:

Synonyms:

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Chemical Property of Boronic acid, [2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)thio]phenyl]-

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Technology Process of Boronic acid, [2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)thio]phenyl]-

There total 6 articles about Boronic acid, [2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)thio]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1-bromo-2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]benzene

: 248270-00-0
{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]phenyl}boronic acid

Guidance literature:: 1-bromo-2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]benzene; With n-butyllithium; In diethyl ether; hexane; at -60 ℃; for 0.333333h;

With Trimethyl borate; In diethyl ether; hexane; at -60 ℃; for 0.166667h;

With sulfuric acid; water; In diethyl ether; hexane; at -20 - 20 ℃; for 2h;

Reference yield:

: 874804-12-3
5-bromo-4-fluoro-2-methylbenzenesulfonyl chloride

: 248270-00-0
{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]phenyl}boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus / iodine / acetic acid / 2 h / Heating / reflux

2.1: potassium hydroxide; water / methanol / 0.5 h / 50 °C

3.1: rongalite; potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: n-butyllithium / diethyl ether; hexane / 0.33 h / -60 °C

4.2: 0.17 h / -60 °C

4.3: 2 h / -20 - 20 °C

With phosphorus; potassium hydroxide; n-butyllithium; water; rongalite; potassium carbonate; iodine; In methanol; diethyl ether; hexane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 452-74-4
4-bromo-3-fluorotoluene

: 248270-00-0
{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]phenyl}boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 1 h / 50 - 60 °C

2.1: phosphorus / iodine / acetic acid / 2 h / Heating / reflux

3.1: potassium hydroxide; water / methanol / 0.5 h / 50 °C

4.1: rongalite; potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: n-butyllithium / diethyl ether; hexane / 0.33 h / -60 °C

5.2: 0.17 h / -60 °C

5.3: 2 h / -20 - 20 °C

With chlorosulfonic acid; phosphorus; potassium hydroxide; n-butyllithium; water; rongalite; potassium carbonate; iodine; In methanol; diethyl ether; hexane; acetic acid; N,N-dimethyl-formamide;