3-TERT-BUTOXYCARBONYLAMINO-4-METHYL-PENTANOIC ACID

Base Information

• Chemical Name: 3-TERT-BUTOXYCARBONYLAMINO-4-METHYL-PENTANOIC ACID
• CAS No.: 248924-39-2
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.292
• Hs Code.: 2924199090
• Mol file: 248924-39-2.mol

Synonyms:DL-3-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid;3-tert-butoxycarbonylamino-4-methylpentanoic acid;3-(Boc-amino)-4-methylpentanoic acid;

Chemical Property of 3-TERT-BUTOXYCARBONYLAMINO-4-METHYL-PENTANOIC ACID

Chemical Property:

• Vapor Pressure: 3.59E-06mmHg at 25°C
• Boiling Point: 360.4oC at 760 mmHg
• Flash Point: 171.8oC
• PSA: 75.63000
• Density: 1.061g/cm3
• LogP: 2.40130

Purity/Quality:

98%min ^*data from raw suppliers

N-Boc-(+/-)-3-Amino-4-methyl-pentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TERT-BUTOXYCARBONYLAMINO-4-METHYL-PENTANOIC ACID

There total 9 articles about 3-TERT-BUTOXYCARBONYLAMINO-4-METHYL-PENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

[(1SR,3RS,4RS)-3,4-dihydroxy-1-isopropyl-pentyl]-carbamic acid tert-butyl ester → 3-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid (248924-39-2)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; at 20 ℃;

DOI:10.1021/ja0298747

Reference yield:

(1RS)-1-[(5RS)-3-isopropyl-4,5-dihydro-isoxazol-5-yl]-ethanol (557091-69-7) → 3-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid (248924-39-2)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran

2: 76 percent / NaIO₄; RuCl₃

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/ja0431713

Reference yield:

(2R,3R)-5-Amino-6-methyl-heptane-2,3-diol → 3-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid (248924-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NaIO₄; RuCl₃

With ruthenium trichloride; sodium periodate;

DOI:10.1021/ja0431713

upstream raw materials:

C₁₅H₃₀N₂O₄

C₁₀H₂₀N₄O₂

di-tert-butyl dicarbonate

(1RS)-1-[(5RS)-3-isopropyl-4,5-dihydro-isoxazol-5-yl]-ethanol