Benzo[b]thiophen-4(5H)-one, 2-bromo-6,7-dihydro-

Base Information

• Chemical Name: Benzo[b]thiophen-4(5H)-one, 2-bromo-6,7-dihydro-
• CAS No.: 25074-25-3
• Molecular Formula: C8H7BrOS
• Molecular Weight: 231.113
• Hs Code.: 2934999090
• Mol file: 25074-25-3.mol

Synonyms:2-bromo-4-oxo-4,5,6,7-tetrahydrobenzothiophene;2-bromo-4,5,6,7-tetrahydro-1-benzothiophen-4-one;2-bromo-4-keto-4,5,6,7-tetrahydrothianapthene;

Chemical Property of Benzo[b]thiophen-4(5H)-one, 2-bromo-6,7-dihydro-

Chemical Property:

• PSA: 45.31000
• LogP: 3.02960
• Storage Temp.: 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

2-Bromo-4,5,6,7-tetrahydro-1-benzothiophen-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophen-4(5H)-one, 2-bromo-6,7-dihydro-

There total 1 articles about Benzo[b]thiophen-4(5H)-one, 2-bromo-6,7-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-keto-4,5,6,7-tetrahydrothianaphthene (13414-95-4) → 4,5,6,7-tetrahydro-2-bromo-4-oxobenzo(b)thiophene (25074-25-3)

Guidance literature:

With bromine; sodium hydroxide; In water; acetic acid; at 0 - 20 ℃; for 18h;

Reference yield: 95.0%

4,5,6,7-tetrahydro-2-bromo-4-oxobenzo(b)thiophene (25074-25-3) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 2-(3-methoxyphenyl)-6,7-dihydro-5H-benzo[b]thiophen-4-one (851024-15-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; for 12h; Heating / reflux;

Reference yield: 65.0%

4,5,6,7-tetrahydro-2-bromo-4-oxobenzo(b)thiophene (25074-25-3) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → 2-(3-(trifluoromethyl)phenyl)-6,7-dihydrobenzo[b]thiophen-4(5H)-one

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

4-keto-4,5,6,7-tetrahydrothianaphthene

Downstream raw materials:

2-(3-methoxyphenyl)-6,7-dihydro-5H-benzo[b]thiophen-4-one