2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl-

Base Information

• Chemical Name: 2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl-
• CAS No.: 135304-82-4
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.1659
• DSSTox Substance ID: DTXSID00159305
• Nikkaji Number: J544.042D
• Wikidata: Q83027610
• Mol file: 135304-82-4.mol

Synonyms:5-Hydroxy-1,3,6-trimethyluracil;2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl-;135304-82-4;5-Hydroxy-1,3,6-trimethyl-2,4(1H,3H)-pyrimidinedione;DTXSID00159305;1,3,6-Trimethyl-5-hydroxyuracil;LS-135387

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl-

Chemical Property:

• Vapor Pressure: 0.00176mmHg at 25°C
• Boiling Point: 260.5°Cat760mmHg
• Flash Point: 111.3°C
• Density: 1.331g/cm³
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 170.06914219
• Heavy Atom Count: 12
• Complexity: 282

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)N(C(=O)N1C)C)O

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl-

There total 6 articles about 2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-1,3,6-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cis-1,3,6-trimethyl-5-hydroxy-6-methoxy-5,6-dihydro uracil → 5-hydroxy-1,3,6-trimethyluracil (135304-82-4)

Guidance literature:

With pyridine; In dichloromethane; Heating;

DOI:10.1016/0040-4020(95)00380-Q

Reference yield: 88.0%

1,3,6-trimethyluracil-5-ammonium sulfate → 5-hydroxy-1,3,6-trimethyluracil (135304-82-4)

Guidance literature:

With sulfuric acid; In water; at 80 ℃; for 1h;

DOI:10.1134/S1070363220050059

Reference yield: 84.0%

dimethyl sulfate (77-78-1) + 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl ammonium sulfate → 5-hydroxy-6-methyluracil (7417-28-9,10098-27-8) + 5-hydroxy-1,3,6-trimethyluracil (135304-82-4)

Guidance literature:

With sodium hydroxide; In water; at 100 ℃; for 2h; Product distribution; var. ratio of reagents, var. temp., var. time;

DOI:10.1007/BF00781072

upstream raw materials:

dimethyl sulfate