2-(Aminomethyl)-4-thiazolecarboxylic acid

Base Information

• Chemical Name: 2-(Aminomethyl)-4-thiazolecarboxylic acid
• CAS No.: 25438-22-6
• Molecular Formula: C5H6N2O2S
• Molecular Weight: 158.181
• Hs Code.: 2934100090
• Mol file: 25438-22-6.mol

Synonyms:2-(Aminomethyl)-4-thiazolecarboxylic acid;2-aminomethyl-thiazole-4-carboxylic acid;4-Thiazolecarboxylic acid,2-(aminomethyl);2-Aminomethyl-thiazol-4-carbonsaeure;2-Aminomethyl-thiazol-carbonsaeure-(4);

Chemical Property of 2-(Aminomethyl)-4-thiazolecarboxylic acid

Chemical Property:

• PSA: 104.45000
• LogP: 1.00030

Purity/Quality:

97% ^*data from raw suppliers

2-Aminomethyl-thiazole-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(Aminomethyl)-4-thiazolecarboxylic acid

There total 2 articles about 2-(Aminomethyl)-4-thiazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

AcNH-Ala-MeOxz-Val-Deala-MeOxz-Ile-Leu-Thz-Ser-Gly-Gly-MeOxz-Leu-Deala-Oxz-Ala-Gly-Thz-Val-OH → L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + L-isoleucine (73-32-5,959215-79-3,18875-42-8) + Gly-Thz (25438-22-6) + L-Leu-Thz

Guidance literature:

With hydrogenchloride; at 110 ℃; for 1h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.7164/antibiotics.54.1045

Reference yield:

pagoamide A → D-Alanine (338-69-2,25191-17-7,18875-37-1) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + D-Serine (312-84-5,83245-15-2) + L-serin (56-45-1,83245-15-2) + L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + C10H16N2O2S + Gly-Thz (25438-22-6)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; for 16h; Sealed tube;

DOI:10.1021/acs.jnatprod.9b01019

Reference yield:

Gly-Thz (25438-22-6) + Nα-(2,4-dinitro-5-fluorophenyl)-D-alaninamide (95713-52-3) → C14H14N6O7S

Guidance literature:

With sodium hydrogencarbonate; In acetone; at 40 ℃; for 1h;

DOI:10.1021/acs.jnatprod.9b01019

Downstream raw materials:

2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylic acid

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