4-Oxazolemethanol, 2,5-diphenyl-

Base Information

• Chemical Name: 4-Oxazolemethanol, 2,5-diphenyl-
• CAS No.: 2549-35-1
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• DSSTox Substance ID: DTXSID90464450
• Nikkaji Number: J925.270C
• Wikidata: Q82289766
• Mol file: 2549-35-1.mol

Synonyms:4-Oxazolemethanol, 2,5-diphenyl-;2549-35-1;(2,5-Diphenyloxazol-4-yl)methanol;(2,5-diphenyl-1,3-oxazol-4-yl)methanol;SCHEMBL7796083;DTXSID90464450;4-hydroxymethyl-2,5-diphenyloxazole

Chemical Property of 4-Oxazolemethanol, 2,5-diphenyl-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 272

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(O2)C3=CC=CC=C3)CO

Technology Process of 4-Oxazolemethanol, 2,5-diphenyl-

There total 15 articles about 4-Oxazolemethanol, 2,5-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2,5-diphenyloxazole-4-carboxylate (93729-29-4) → 2,5-diphenyl-4-hydroxymethyloxazole (2549-35-1)

Guidance literature:

With lithium borohydride; lithium triethylborohydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2004.01.034

Reference yield: 92.0%

methyl 2,5-diphenyloxazole-4-carboxylate (25755-94-6) → 2,5-diphenyl-4-hydroxymethyloxazole (2549-35-1)

Guidance literature:

methyl 2,5-diphenyloxazole-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With water; In tetrahydrofuran; at 0 ℃;

DOI:10.1039/c2cc00081d

Reference yield: 33.0%

2,5-diphenyloxazole (92-71-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,5-diphenyl-4-hydroxymethyloxazole (2549-35-1)

Guidance literature:

2,5-diphenyloxazole; With sec.-butyllithium; thymidine 5'-phosphate; In tetrahydrofuran; at -75 - 0 ℃;

N,N-dimethyl-formamide; at 20 ℃; for 10h;

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.tetlet.2004.01.034

upstream raw materials:

4-(chloromethyl)-2,5-diphenyloxazole

ethyl 2,5-diphenyloxazole-4-carboxylate

2,5-diphenyloxazole

N,N-dimethyl-formamide

Downstream raw materials:

4-bromomethyl-2,5-diphenyloxazole

4-formyl-2,5-diphenyloxazole

6-(2,5-diphenyl-oxazol-4-ylmethoxy)-hexan-1-ol

4-hydroxymethyl-2,5-diphenyloxazole acrylate