(1-tert-Butylaziridin-2-yl)methanol

Base Information

• Chemical Name: (1-tert-Butylaziridin-2-yl)methanol
• CAS No.: 25665-28-5
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• DSSTox Substance ID: DTXSID50498039
• Mol file: 25665-28-5.mol

Synonyms:(1-tert-Butylaziridin-2-yl)methanol;25665-28-5;DTXSID50498039

Chemical Property of (1-tert-Butylaziridin-2-yl)methanol

Chemical Property:

• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 106

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)N1CC1CO

Technology Process of (1-tert-Butylaziridin-2-yl)methanol

There total 1 articles about (1-tert-Butylaziridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine (13080-65-4) → N-tert-butyl-3-hydroxyazetidine (13156-04-2) + 1-(tert-butyl)-2-(hydroxymethyl)aziridine (25665-28-5)

Guidance literature:

With magnesium bromide; In 1,4-dioxane; for 3h; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/S0040-4039(97)01360-9

Reference yield: 94.0%

1-(tert-butyl)-2-(hydroxymethyl)aziridine (25665-28-5) + p-toluenesulfonyl chloride (98-59-9) → 1-tert-butyl-2-(tosyloxymethyl)aziridine (23398-26-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1055/s-2003-45001

upstream raw materials:

2-methyl-N-(oxiran-2-ylmethyl)propan-2-amine

Downstream raw materials:

1-tert-butyl-2-(tosyloxymethyl)aziridine