Technology Process of 1(2H)-Quinolinecarboxylic acid,
4-amino-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
There total 9 articles about 1(2H)-Quinolinecarboxylic acid,
4-amino-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen; ammonium formate;
In
methanol; water;
for 2h;
Heating;
DOI:10.1016/j.ejmech.2016.09.098
- Guidance literature:
-
With
O,O'-dibenzoyl-L-tartaric acid;
In
ethanol;
at 5 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: caesium carbonate; palladium diacetate; DavePhos; phenylboronic acid / toluene / 4 h / 80 °C / Schlenk technique; Inert atmosphere
2: sulfuric acid / toluene / 10 h / Heating
3: lithium tert-butoxide / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice
4: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 0.25 h / Cooling with acetone-dry ice
5: pyridine / dichloromethane / 0.83 h
6: ammonium formate; hydrogen; palladium 10% on activated carbon / water; methanol / 2 h / Heating
With
pyridine; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; ammonium formate; palladium diacetate; caesium carbonate; lithium tert-butoxide; DavePhos; phenylboronic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2016.09.098
