4-tert-butyl-3-formyl-1H-pyrazol-5-yl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 4-tert-butyl-3-formyl-1H-pyrazol-5-yl 4-methylbenzenesulfonate
• CAS No.: 265643-79-6
• Molecular Formula: C15H18N2O4S
• Molecular Weight: 322.385
• Mol file: 265643-79-6.mol

Synonyms:Toluene-4-sulfonic acid 4-tert-butyl-5-formyl-1H-pyrazol-3-yl ester;4-tert-butyl-5-formyl-3-(p-toluenesulfonyloxy)pyrazole;

Chemical Property of 4-tert-butyl-3-formyl-1H-pyrazol-5-yl 4-methylbenzenesulfonate

Chemical Property:

• PSA: 97.50000
• LogP: 3.67660

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-tert-butyl-3-formyl-1H-pyrazol-5-yl 4-methylbenzenesulfonate

There total 6 articles about 4-tert-butyl-3-formyl-1H-pyrazol-5-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-tert-Butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole (265643-79-6)

Guidance literature:

Reference yield: 95.0%

4-tert-butyl-3-(hydroxymethyl)-1H-pyrazol-5-yl 4-methylbenzenesulfonate (265643-78-5) → 4-tert-butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole (265643-79-6)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 24h; Heating;

DOI:10.1021/jm040863t

Reference yield:

4-tert-butyl-3-hydroxy-5-hydroxymethylpyrazole (265643-77-4,342652-78-2) → 4-tert-butyl-5-formyl-3-[(4-methylphenyl)sulphonyloxy]pyrazole (265643-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: 95 percent / MnO₂ / CHCl₃ / 24 h / Heating

With manganese(IV) oxide; triethylamine; In dichloromethane; chloroform;

DOI:10.1021/jm040863t

upstream raw materials:

4-tert-butyl-3-(hydroxymethyl)-1H-pyrazol-5-yl 4-methylbenzenesulfonate

p-toluenesulfonyl chloride

4-tert-butyl-3-hydroxy-5-hydroxymethylpyrazole

3-(1,1-dimethyleth-1-yl)-4-hydroxy-2(5H)-furanone

Downstream raw materials:

3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-[(4-methylphenyl)sulphonyloxy]pyrazolo[1,5-d][1,2,4]triazine

3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine

toluene-4-sulfonic acid 3-tert-butyl-7-(5-hydroxymethyl-isoxazol-3-yl)-pyrazolo[1,5-d][1,2,4]triazin-2-yl ester

4-tert-butyl-5-(toluene-4-sulfonyloxy)-2H-pyrazole-3-carboxylic acid