4-(2-Methoxy-phenyl)-1H-indole

Base Information

• Chemical Name: 4-(2-Methoxy-phenyl)-1H-indole
• CAS No.: 266678-13-1
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol file: 266678-13-1.mol

Synonyms:4-(2-Methoxy-phenyl)-1H-indole;

Chemical Property of 4-(2-Methoxy-phenyl)-1H-indole

Chemical Property:

• Melting Point: 172 °C
• Boiling Point: 387.8±17.0 °C(Predicted)
• PKA: 16.89±0.30(Predicted)
• PSA: 25.02000
• Density: 1.167±0.06 g/cm3(Predicted)
• LogP: 3.84350

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-Methoxy-phenyl)-1H-indole

There total 11 articles about 4-(2-Methoxy-phenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-(2-methoxyphenyl)-2,3-dihydro-1H-indole (212119-12-5) → 4-(2-methoxyphenyl)-1H-indole (266678-13-1)

Guidance literature:

With TEMPOL; oxygen; copper(l) chloride; at 50 - 60 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/chem.202004107

Reference yield: 48.0%

4-bromo-1H-indole (52488-36-5) + 2-Methoxyphenylboronic acid (5720-06-9) → 4-(2-methoxyphenyl)-1H-indole (266678-13-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol;

DOI:10.1016/S0040-4039(99)02204-2

Reference yield:

1-[(E)-2-(2'-Methoxy-3-nitro-biphenyl-2-yl)-vinyl]-pyrrolidine → 4-(2-methoxyphenyl)-1H-indole (266678-13-1)

Guidance literature:

With hydrazine; nickel; In tetrahydrofuran; methanol; water; at 50 ℃; for 3.5h;

DOI:10.1016/S0040-4039(99)02204-2

upstream raw materials:

4-bromo-1H-indole

2-Methoxyphenylboronic acid

2-bromo-6-nitrotoluene

2'-Methoxy-2-methyl-3-nitro-biphenyl

Downstream raw materials:

2-{2-[4-(2-methoxyphenyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one

4-(2-methoxyphenyl)-2,3-dihydro-1H-indole

Refernces

• 1、 -. "NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS". Paragraph 3043-3049. . Retrieved 2013/10/22.
• 2、 Batt, Douglas G.,Petraitis, Joseph J.,Sherk, Susan R.,Copeland, Robert A.,Dowling, Randine L.,Taylor, Tracy L.,Jones, Elizabeth A.,Magolda, Ronald L.,Jaffee, Bruce D.. "Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents". . p. 1745 - 1750. Retrieved 2007/10/03.