(2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate
CAS No.:267420-70-2
Molecular Formula:C17H31NO6Si
Molecular Weight:373.51700
Hs Code.:
Mol file:267420-70-2.mol

Synonyms:(2S,4R)-1-tert-butyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate;(3R,5S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)-5-(methoxycarbonyl)pyrrolidin-2-one;(3R,5S)-1-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxy-5-methoxycarbonylpyrrolidin-2-one;methyl-1-tert-butyl-(2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-oxopyrrolidine-1,2-dicarboxylate;1-tert-butyl-2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-oxo-pyrrolidine-1,2-dicarboxylate;

Suppliers and Price of (2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Chemical Property:

PSA：82.14000
LogP:3.02370

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

There total 12 articles about (2S,4R)-1-tert-butyl 2-Methyl 4-((tert-butyldiMethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114676-91-4
1-tert-butyl 2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidine-1,2-dicarboxylate

: 267420-70-2
1-(tert-butyl) 2-methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium periodate; ruthenium(IV) oxide; In water; ethyl acetate; at 20 ℃; for 18h;
DOI:10.1016/S0040-4039(01)01030-9

Reference yield: 84.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 267420-68-8
(3R,5S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)-5-(2-furyl)pyrrolidin-2-one

: 267420-70-2
1-(tert-butyl) 2-methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: (3R,5S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)-5-(2-furyl)pyrrolidin-2-one; With ruthenium(IV) oxide; sodium periodate; sodium hydrogencarbonate; In tetrachloromethane; water; acetonitrile;

diazomethane; In diethyl ether; at 0 ℃; Further stages.;
DOI:10.1021/jo991560n

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 267420-70-2
1-(tert-butyl) 2-methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide

2: sodium periodate; ruthenium(IV) oxide / water; ethyl acetate

With 1H-imidazole; ruthenium(IV) oxide; sodium periodate; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo2004617