Metoprolol hydrochloride

Base Information

Chemical Name:Metoprolol hydrochloride
CAS No.:56392-18-8
Molecular Formula:C₁₅H₂₅NO₃*ClH
Molecular Weight:303.829
Hs Code.:
UNII:AS4SUC4LC5
DSSTox Substance ID:DTXSID10971818
ChEMBL ID:CHEMBL545787

Synonyms:Metoprolol hydrochloride;56392-18-8;Metoprolol HCl;AS4SUC4LC5;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol hydrochloride;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride;(+-)-1-(4-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol hydrochloride;(+/-)-Metoprolol-d7 hydrochloride (iso-propyl-d7);2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, hydrochloride, (+-)-;UNII-AS4SUC4LC5;CHEMBL545787;SCHEMBL2638034;DTXSID10971818;AKOS025392154;AK-0037;LS-122451;1-[4-(2-Methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol--hydrogen chloride (1/1);2-PROPANOL, 1-(4-(2-METHOXYETHYL)PHENOXY)-3-((1-METHYLETHYL)AMINO)-, HYDROCHLORIDE;2-PROPANOL, 1-(4-(2-METHOXYETHYL)PHENOXY)-3-((1-METHYLETHYL)AMINO)-, HYDROCHLORIDE (1:1);2-PROPANOL, 1-(4-(2-METHOXYETHYL)PHENOXY)-3-((1-METHYLETHYL)AMINO)-, HYDROCHLORIDE, (+/-)-

Suppliers and Price of Metoprolol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Metoprolol hydrochloride

Chemical Property:

Vapor Pressure:4.52E-07mmHg at 25°C
Boiling Point:398.6°Cat760mmHg
Flash Point:194.9°C
Density:g/cm³
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:303.1601214
Heavy Atom Count:20
Complexity:215

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.Cl

Technology Process of Metoprolol hydrochloride

There total 5 articles about Metoprolol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 81024-42-2,37350-58-6
S-(-)-metoprolol

: 114218-35-8,56392-18-8
(-)-Metoprolol hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 1h; Heating;
DOI:10.3987/com-98-8169

Reference yield:

: 128084-02-6
N-isopropyl-3-<<4'-(2''-methoxyethyl)phenyl>oxy>-2-oxo-1-propylamine hydrochloride

: 68985-04-6,56392-18-8
(+)-Metoprolol hydrochloride

: 114218-35-8,56392-18-8
(-)-Metoprolol hydrochloride

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triethylamine; (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; In methanol; at 50 ℃; for 20h; under 14710.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

: 128084-02-6
N-isopropyl-3-<<4'-(2''-methoxyethyl)phenyl>oxy>-2-oxo-1-propylamine hydrochloride

: 68985-04-6,56392-18-8
(+)-Metoprolol hydrochloride

: 114218-35-8,56392-18-8
(-)-Metoprolol hydrochloride

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triethylamine; (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; In methanol; at 50 ℃; for 20h; under 14710.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;