5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Base Information

Chemical Name:5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-
CAS No.:268736-74-9
Molecular Formula:C13H24O2Si
Molecular Weight:240.418
Hs Code.:

Synonyms:

Suppliers and Price of 5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

There total 1 articles about 5-Heptynal, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 268736-74-9
2-(tert-butyl-dimethyl-silanyloxy)-hept-5-ynal

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / Inert atmosphere; Reflux

2: triphenylphosphine / tetrahydrofuran / 4 h / Reflux; Inert atmosphere

3: 1,2-diamino-benzene; iron(III)-acetylacetonate / diethyl ether / 1.5 h / 0 - 20 °C / Inert atmosphere

4: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5: dimethylboron bromide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

6: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; iron(III)-acetylacetonate; dimethylboron bromide; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; 1,2-diamino-benzene; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; 2: |Wittig Olefination;
DOI:10.1002/chem.201404873

Reference yield:

: 268736-74-9
2-(tert-butyl-dimethyl-silanyloxy)-hept-5-ynal

: 400736-32-5
(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-4-methoxy-dec-8-ynal

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 1 h / -100 °C

1.2: 85 percent / NaBO₃*4H₂O / tetrahydrofuran; H₂O / 12 h / 25 °C

2.1: 85 percent / 2,6-di-tert-butyl-4-methyl pyridine / CH₂Cl₂ / 24 h / 40 °C

3.1: 85 percent / K₃[Fe(CN)6]; K₂CO₃; (DHQ)2*PYR / OsO₄ / 2-methyl-propan-2-ol; H₂O / 12 h / 0 °C

4.1: 99 percent / CSA / toluene / 12 h / 110 °C

5.1: 70 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

6.1: 95 percent / SO₃*py; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 0.5 h / 0 - 25 °C

With 2,6-di-tert-butyl-4-methylpyridine; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); pyridine-SO₃ complex; camphor-10-sulfonic acid; diisobutylaluminium hydride; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); osmium(VIII) oxide; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; tert-butyl alcohol;
DOI:10.1002/1521-3773(20011015)40:20<3849::AID-ANIE3849>3.0.CO;2-M

Reference yield:

: 268736-74-9
2-(tert-butyl-dimethyl-silanyloxy)-hept-5-ynal

: 400737-13-5
tert-Butyl-((S)-1-{(S)-2-[(S)-2-(3,4-dimethoxy-phenyl)-[1,3]dioxolan-4-yl]-1-methoxy-ethyl}-hex-4-ynyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / 1 h / -100 °C

1.2: 85 percent / NaBO₃*4H₂O / tetrahydrofuran; H₂O / 12 h / 25 °C

2.1: 85 percent / 2,6-di-tert-butyl-4-methyl pyridine / CH₂Cl₂ / 24 h / 40 °C

3.1: 85 percent / K₃[Fe(CN)6]; K₂CO₃; (DHQ)2*PYR / OsO₄ / 2-methyl-propan-2-ol; H₂O / 12 h / 0 °C

4.1: 99 percent / CSA / toluene / 12 h / 110 °C

With 2,6-di-tert-butyl-4-methylpyridine; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); camphor-10-sulfonic acid; potassium carbonate; potassium hexacyanoferrate(III); osmium(VIII) oxide; In diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1002/1521-3773(20011015)40:20<3849::AID-ANIE3849>3.0.CO;2-M