2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester
• CAS No.: 27172-03-8
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.23200
• Mol file: 27172-03-8.mol

Synonyms:2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester;2-ethyl-5-methyl-pyrrole-3-carboxylic acid ethyl ester;

Chemical Property of 2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property:

• PSA: 42.09000
• LogP: 2.06220

Purity/Quality:

99% ^*data from raw suppliers

2-ethyl-5-methyl-1H-Pyrrole-3-carboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

There total 4 articles about 2-Ethyl-5-methyl-1H-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-oxo-2-(2-oxo-propyl)-pentanoic acid ethyl ester (77596-93-1) → ethyl 2-ethyl-5-methyl-1H-pyrrole-3-carboxylate (27172-03-8)

Guidance literature:

With ammonium acetate; acetic acid; at 80 ℃; for 3h;

Reference yield: 77.0%

C10H14O2 → ethyl 2-ethyl-5-methyl-1H-pyrrole-3-carboxylate (27172-03-8)

Guidance literature:

With sodium azide; In tert-butyl alcohol; at 65 ℃; for 24h;

DOI:10.1021/jo062376m

Reference yield:

ethyl propanoylacetate (4949-44-4) → ethyl 2-ethyl-5-methyl-1H-pyrrole-3-carboxylate (27172-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: ammonium acetate; acetic acid / 3 h / 80 °C

With ammonium acetate; sodium hydride; acetic acid; In tetrahydrofuran; mineral oil;

upstream raw materials:

3-oxo-2-(2-oxo-propyl)-pentanoic acid ethyl ester

ethyl propanoylacetate