Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-

Base Information

Chemical Name:Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-
CAS No.:273749-30-7
Molecular Formula:C17H17N3O2
Molecular Weight:295.341
Hs Code.:
DSSTox Substance ID:DTXSID80463139
Nikkaji Number:J2.032.021D
Wikidata:Q82287933

Synonyms:273749-30-7;2-(4-(1,3-Dioxolan-2-yl)-1-methyl-1H-benzo[d]imidazol-2-yl)aniline;Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-;SCHEMBL7254841;DTXSID80463139;TVDUQLKSYKKNEJ-UHFFFAOYSA-N;1-Methyl-2-(2-aminophenyl)-benzimidazole-4-carboxaldehyde ethylene acetal

Suppliers and Price of Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:295.132076794
Heavy Atom Count:22
Complexity:388

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=CC=CC(=C2N=C1C3=CC=CC=C3N)C4OCCO4

Technology Process of Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]-

There total 11 articles about Benzenamine, 2-[4-(1,3-dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 560086-62-6
benzyl [2-(4-[1,3]dioxolan-1-yl-1-methyl-1H-benzimidazol-2-yl)phenyl]carbamate

: 273749-30-7
2-(4-([1,3]dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl)phenylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 17h; atmospheric pressure;
DOI:10.1021/ol049954a

Reference yield: 91.0%

: 273749-29-4
4-([1,3]dioxolan-2-yl)-1-methyl-2-(2-nitrophenyl)-1H-benzimidazole

: 273749-30-7
2-(4-([1,3]dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl)phenylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; atmospheric pressure;
DOI:10.1021/ol049954a

Reference yield:

: 560086-19-3
1-methyl-2-(2-nitrophenyl)-1H-benzimidazole-4-carboxylic acid

: 273749-30-7
2-(4-([1,3]dioxolan-2-yl)-1-methyl-1H-benzimidazol-2-yl)phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / BH₃*THF / tetrahydrofuran / 17 h / 0 - 20 °C

2: 78 percent / MnO₂ / CH₂Cl₂ / 18 h

3: 86 percent / p-TSA*H₂O / benzene / 17 h / Heating

4: 91 percent / H₂ / Pd/C / methanol / 3 h / atmospheric pressure

With manganese(IV) oxide; borane-THF; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ol049954a