1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Base Information

• Chemical Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
• CAS No.: 280110-69-2
• Molecular Formula: C13H21N3O3
• Molecular Weight: 267.328
• Hs Code.: 2934999090
• Mol file: 280110-69-2.mol

Synonyms:1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine;4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid ter-butyl ester;4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Chemical Property:

• Vapor Pressure: 4.21E-06mmHg at 25°C
• Melting Point: 69 °C
• Boiling Point: 384oC at 760 mmHg
• PKA: -2.58±0.40(Predicted)
• Flash Point: 186.1oC
• PSA: 68.46000
• Density: 1.14g/cm3
• LogP: 2.43040
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

There total 5 articles about 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (187834-88-4) → 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (280110-69-2)

Guidance literature:

N,N-dimethylacetamide dimethyl acetal; tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate; In tetrahydrofuran; at 50 ℃; for 4h;

With toluene-4-sulfonic acid; In toluene; at 100 ℃; for 18h;

Reference yield: 81.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (187834-88-4) → 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (280110-69-2)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate; In tetrahydrofuran; at 50 ℃; for 4h;

With toluene-4-sulfonic acid; In toluene; at 100 ℃; for 18h;

Reference yield: 66.0%

Triethyl orthoacetate (78-39-7) + tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (187834-88-4) → 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (280110-69-2)

Guidance literature:

for 7h; Reflux;

DOI:10.1021/jm701562x

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

Triethyl orthoacetate

tert-butyl 4-(2-acetylhydrazinecarbonyl)piperidine-1-carboxylate.

Downstream raw materials:

4-(4-benzyl-5-methyl-4H-[1,2,4]triazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester

4-[4-(4-chloro-phenyl)-5-methyl-4H-[1,2,4]triazol-3-yl]-piperidine

4-[4-(4-chloro-phenyl)-5-methyl-4H-[1,2,4]triazol-3-yl]-piperidine hydrochloride

2-methyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 280110-69-2 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send