2-Benzofurancarboxamide, N-[(1S)-1-[[[(4R)-hexahydro-3-oxo-1-(2-pyridinylsulfonyl)-1H-azepin-4-yl ]amino]carbonyl]-3-methylbutyl]-

Base Information

• Chemical Name: 2-Benzofurancarboxamide, N-[(1S)-1-[[[(4R)-hexahydro-3-oxo-1-(2-pyridinylsulfonyl)-1H-azepin-4-yl ]amino]carbonyl]-3-methylbutyl]-
• CAS No.: 281214-75-3
• Molecular Formula: C26H30N4O6S
• Mol file: 281214-75-3.mol

Synonyms:

Chemical Property of 2-Benzofurancarboxamide, N-[(1S)-1-[[[(4R)-hexahydro-3-oxo-1-(2-pyridinylsulfonyl)-1H-azepin-4-yl ]amino]carbonyl]-3-methylbutyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzofurancarboxamide, N-[(1S)-1-[[[(4R)-hexahydro-3-oxo-1-(2-pyridinylsulfonyl)-1H-azepin-4-yl ]amino]carbonyl]-3-methylbutyl]-

There total 2 articles about 2-Benzofurancarboxamide, N-[(1S)-1-[[[(4R)-hexahydro-3-oxo-1-(2-pyridinylsulfonyl)-1H-azepin-4-yl ]amino]carbonyl]-3-methylbutyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzofuran-2-carboxylic acid {(S)-3-methyl-1-[3-hydroxy-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}amide (281219-76-9) → Benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(R)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide (281214-75-3) + SB 357114 (281217-45-6)

Guidance literature:

With pyridine-SO₃ complex; TEA; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1021/jm000481x

Reference yield:

tert-butyl 4-methyl-1-oxo-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylamino]pentan-2-ylcarbamate (882529-78-4) + Benzofuran-2-carboxylic acid (496-41-3) → Benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(R)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide (281214-75-3) + SB 357114 (281217-45-6)

Guidance literature:

tert-butyl 4-methyl-1-oxo-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylamino]pentan-2-ylcarbamate; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2.5h;

Benzofuran-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.3987/COM-05-S(T)65

Reference yield:

Benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(R)-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide (281214-75-3) → SB 357114 (281217-45-6)

Guidance literature:

With phosphate buffer; pH=11; Further Variations:; pH-values; Kinetics;

DOI:10.1021/jm000481x

upstream raw materials:

benzofuran-2-carboxylic acid {(S)-3-methyl-1-[3-hydroxy-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}amide

tert-butyl 4-methyl-1-oxo-1-[3-oxo-1-(pyridine-2-sulfonyl)azepan-4-ylamino]pentan-2-ylcarbamate

Benzofuran-2-carboxylic acid

Downstream raw materials:

SB 357114