1-Piperidinecarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]thio]methyl]-4-[(hydroxyamino)carbonyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]thio]methyl]-4-[(hydroxyamino)carbonyl]-, 1,1-dimethylethyl ester
• CAS No.: 287200-97-9
• Molecular Formula: C22H30N2O5S
• Molecular Weight: 434.557
• Mol file: 287200-97-9.mol

Synonyms:

Chemical Property of 1-Piperidinecarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]thio]methyl]-4-[(hydroxyamino)carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]thio]methyl]-4-[(hydroxyamino)carbonyl]-, 1,1-dimethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 4-[[[4-(2-butynyloxy)phenyl]thio]methyl]-4-[(hydroxyamino)carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-(4-but-2-ynyloxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (287202-24-8) → tert-butyl-4-({[4-(2-butynyloxy)phenyl]sulfanyl}methyl)-4-[(hydroxyamino)-carbonyl]-1-piperidinecarboxylate (287200-97-9)

Guidance literature:

4-(4-but-2-ynyloxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

With hydroxylamine; In DMF (N,N-dimethyl-formamide); water; for 18h;

Reference yield: 77.0%

tert-butyl-4-({[4-(2-butynyloxy)phenyl]sulfanyl}methyl)-4-[(hydroxyamino)-carbonyl]-1-piperidinecarboxylate (287200-97-9) → tert-Butyl-4-({[4-(but-2-ynyloxy)phenyl]sulfonyl}methyl)-4-[(hydroxyamino)-carbonyl]piperidine-1-carboxylate

Guidance literature:

With oxone; In tetrahydrofuran; methanol; dichloromethane; water; at 20 ℃; for 18h;

Reference yield: 76.0%

tert-butyl-4-({[4-(2-butynyloxy)phenyl]sulfanyl}methyl)-4-[(hydroxyamino)-carbonyl]-1-piperidinecarboxylate (287200-97-9) → 4-({[4-(But-2-ynyloxy)phenyl] thio}methyl)-N-hydroxypiperidine-4-carboxamide

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; for 1h;

upstream raw materials:

4-(4-but-2-ynyloxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Downstream raw materials:

tert-butyl-4-({[4-(2-butynyloxy)phenyl]sulfinyl}methyl)-4-[(hydroxyamino)-carbonyl]-1-piperidinecarboxylate