Chemical Property of 8-hydroxyloxapine
Chemical Property:
- Vapor Pressure:1.38E-11mmHg at 25°C
- Melting Point:212-215°C
- Boiling Point:523.7°C at 760 mmHg
- Flash Point:270.5°C
- PSA：48.30000
- Density:1.39g/cm3
- LogP:2.78840
- Storage Temp.:Amber Vial, -20°C Freezer, Under Inert Atmosphere
- Purity/Quality:
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99% *data from raw suppliers
8-Hydroxy Loxapine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
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Uses
The inactive
