4-BROMO-1-CHLORO-2-ETHYLBENZENE

Base Information

• Chemical Name: 4-BROMO-1-CHLORO-2-ETHYLBENZENE
• CAS No.: 289039-22-1
• Molecular Formula: C8H8BrCl
• Molecular Weight: 219.509
• Hs Code.: 2903999090
• Mol file: 289039-22-1.mol

Synonyms:4-Bromo-1-chloro-2-ethylbenzene;5-Bromo-2-chloroethylbenzene;

Chemical Property of 4-BROMO-1-CHLORO-2-ETHYLBENZENE

Chemical Property:

• Appearance/Colour: colorless liquid
• Vapor Pressure: 0.0778mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 235.1 °C at 760 mmHg
• Flash Point: 116.2 °C
• PSA: 0.00000
• Density: 1.459 g/cm³
• LogP: 3.66490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-1-chloro-2-ethylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-1-CHLORO-2-ETHYLBENZENE

There total 1 articles about 4-BROMO-1-CHLORO-2-ETHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(2-bromo-5-chlorophenyl)ethan-1-one (105884-19-3) → 4-bromo-1-chloro-2-ethyl-benzene (289039-22-1)

Guidance literature:

With sodium hydroxide; hydrazine; In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; at 170 ℃; for 24h;

Reference yield: 90.0%

4-bromo-1-chloro-2-ethyl-benzene (289039-22-1) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → (E)-3-(4-Chloro-3-ethyl-phenyl)-acrylamide (1352659-78-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In 1-methyl-pyrrolidin-2-one; at 80 - 100 ℃; for 21h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

4-bromo-1-chloro-2-ethyl-benzene (289039-22-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-3-ethyl-benzaldehyde (945717-06-6)

Guidance literature:

4-bromo-1-chloro-2-ethyl-benzene; With n-butyllithium; In diethyl ether; hexane; at 0 - 20 ℃; for 2.5h;

N,N-dimethyl-formamide; In diethyl ether; hexane; at 20 - 28 ℃; for 1h;

upstream raw materials:

1-(2-bromo-5-chlorophenyl)ethan-1-one

Downstream raw materials:

4-chloro-3-ethyl-benzaldehyde

(E)-3-(4-Chloro-3-ethyl-phenyl)-acrylamide

3-(4-Chloro-3-ethyl-phenyl)-propionamide

2-(4-Chloro-3-Ethyl-Phenyl)-Ethyl-Amine-Hydrochloride