N-{4-[(benzylamino)sulfonyl]phenyl}acetamide

Base Information

• Chemical Name: N-{4-[(benzylamino)sulfonyl]phenyl}acetamide
• CAS No.: 289061-13-8
• Molecular Formula: C15H16N2O3S
• Molecular Weight: 304.37
• Mol file: 289061-13-8.mol

Synonyms:N-acetyl-sulfanilic acid benzylamide;N-Acetyl-sulfanilsaeure-benzylamid;N-(benzyl)-4-(acetylamino)benzenesulfonamide;Esigsaeure-(4-benzylsulfamoyl-anilid);

Chemical Property of N-{4-[(benzylamino)sulfonyl]phenyl}acetamide

Chemical Property:

• Melting Point: 149 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• PKA: 11.35±0.30(Predicted)
• PSA: 83.65000
• Density: 1.301±0.06 g/cm3(Predicted)
• LogP: 3.66820

Purity/Quality:

N-{4-[(benzylamino)sulfonyl]phenyl}acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-{4-[(benzylamino)sulfonyl]phenyl}acetamide

There total 3 articles about N-{4-[(benzylamino)sulfonyl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzylamine (100-46-9) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-(4-(N-benzylsulfamoyl)phenyl)acetamide (289061-13-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1080/14756366.2020.1765165

Reference yield: 52.8%

→ N-(4-(N-benzylsulfamoyl)phenyl)acetamide (289061-13-8)

Guidance literature:

Reference yield:

benzyl chloride (100-44-7) + p-acetylaminobenzenesulfonamide (121-61-9) → N-(4-(N-benzylsulfamoyl)phenyl)acetamide (289061-13-8)

Guidance literature:

upstream raw materials:

benzyl chloride

p-acetylaminobenzenesulfonamide

benzylamine

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

N-benzyl-4-aminobenzenesulfonamide