(5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene

Base Information

Chemical Name:(5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene
CAS No.:28908-27-2
Molecular Formula:C15H22
Molecular Weight:202.33500
Hs Code.:
Mol file:28908-27-2.mol

Synonyms:(5R,10R)-2-Isopropylidene-10-methyl-6-methylene-spiro[4.5]dec-7-ene;β-Vetispiren;β-Isovetivenen;

Suppliers and Price of (5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene

Chemical Property:

Boiling Point:284.9±20.0 °C(Predicted)
PSA：0.00000
Density:0.91±0.1 g/cm3(Predicted)
LogP:4.64530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene

There total 20 articles about (5R,10R)-10-Methyl-6-methylene-2-isopropylidenespiro[4.5]dec-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (5R,6S)-6-Methyl-8,10-dioxo-spiro[4.5]dec-1-ene-2-carboxylic acid ethyl ester

: 28908-27-2,50763-70-7,78147-64-5
(+/-)-β-Vetispiren

Guidance literature:: Multi-step reaction with 9 steps

1: TsOH / benzene / Heating

2: aq. HCl

3: TsOH / benzene / Heating

4: H₂ / Pd-C

5: (i), (ii) aq. HCl

6: NaOAc / 140 °C

7: BF₃*Et₂O

8: LiAlH₄

9: (1S)-2-oxo-bornane-10-sulfonic acid

With hydrogenchloride; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; sodium acetate; toluene-4-sulfonic acid; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; palladium on activated charcoal; In benzene;
DOI:10.1021/ja00464a034

Reference yield:

: C₁₅H₂₄O

: C₁₅H₂₂

: 28908-27-2,50763-70-7,78147-64-5
(+/-)-β-Vetispiren

Guidance literature:: With CSA; In dichloromethane; at 20 ℃; for 0.5h; Overall yield = 10.7 mg;
DOI:10.1016/j.tetlet.2019.05.011

Reference yield:

: (5R,10S)-6-Chloro-10-methyl-8-oxo-spiro[4.5]deca-1,6-diene-2-carboxylic acid ethyl ester

: 28908-27-2,50763-70-7,78147-64-5
(+/-)-β-Vetispiren

Guidance literature:: Multi-step reaction with 9 steps

1: NaOEt

2: aq. HCl

3: TsOH / benzene / Heating

4: H₂ / Pd-C

5: (i), (ii) aq. HCl

6: NaOAc / 140 °C

7: BF₃*Et₂O

8: LiAlH₄

9: (1S)-2-oxo-bornane-10-sulfonic acid

With hydrogenchloride; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; sodium ethanolate; sodium acetate; toluene-4-sulfonic acid; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; palladium on activated charcoal; In benzene;
DOI:10.1021/ja00464a034