Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate

Base Information

Chemical Name:Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate
CAS No.:65202-61-1
Molecular Formula:C10H16 N2 O6
Molecular Weight:260.247
Hs Code.:2934999090
European Community (EC) Number:265-617-1
DSSTox Substance ID:DTXSID00983809
Nikkaji Number:J307.333E

Synonyms:65202-61-1;EINECS 265-617-1;Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate;SCHEMBL14430917;DTXSID00983809;10-[(Hydroxyamino)carbonyl]-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylic acid methyl ester;N-Hydroxy-7-(methoxycarbonyl)-1,4-dioxa-7-azaspiro[4.5]decane-10-carboximidic acid

Suppliers and Price of Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：100.82000
Density:1.42g/cm³
LogP:0.10140
XLogP3:-1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:260.10083623
Heavy Atom Count:18
Complexity:341

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)N1CCC(C2(C1)OCCO2)C(=O)NO

Technology Process of Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate

There total 5 articles about Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: dimethyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 65202-61-1
methyl 10-(hydroxycarbamoyl)-1,4-dioxa-7-azaspiro[4.5] decane-7-carboxylate

Guidance literature:: With hydroxylamine hydrochloride; sodium methylate; In methanol; at 0 - 25 ℃; for 15.5h; Large scale;

Reference yield:

: 220223-45-0
ethyl 4-((2-ethoxy-2-oxoethyl(methoxycarbonyl)amino)butanoate)

: 65202-61-1
methyl 10-(hydroxycarbamoyl)-1,4-dioxa-7-azaspiro[4.5] decane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 14 h / 40 °C / Reflux; Large scale

2: toluene; methanesulfonic acid / 9.08 h / 30 °C / Reflux; Large scale

3: hydroxylamine hydrochloride; sodium methylate / methanol / 15.5 h / 0 - 25 °C / Large scale

With hydroxylamine hydrochloride; sodium methylate; In methanol; methanesulfonic acid; toluene;

Reference yield:

: ethyl (E)-4-((2-ethoxy-2-oxoethylidene)amino)butanoate

: 65202-61-1
methyl 10-(hydroxycarbamoyl)-1,4-dioxa-7-azaspiro[4.5] decane-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen; sodium sulfate / toluene / 10 - 20 °C / 750.08 - 1125.11 Torr / Autoclave; Large scale

2: potassium carbonate / toluene / 8 h / -5 - 2 °C / Large scale

3: 14 h / 40 °C / Reflux; Large scale

4: toluene; methanesulfonic acid / 9.08 h / 30 °C / Reflux; Large scale

5: hydroxylamine hydrochloride; sodium methylate / methanol / 15.5 h / 0 - 25 °C / Large scale

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium methylate; potassium carbonate; sodium sulfate; In methanol; methanesulfonic acid; toluene;