Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-

Base Information

Chemical Name:Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-
CAS No.:293732-24-8
Molecular Formula:C8H8BrIO
Molecular Weight:326.959
Hs Code.:
European Community (EC) Number:961-122-6
DSSTox Substance ID:DTXSID50479388
Nikkaji Number:J1.354.370D
Wikidata:Q82313392
Mol file:293732-24-8.mol

Synonyms:2-(bromomethyl)-1-iodo-4-methoxybenzene;293732-24-8;Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-;DTXSID50479388;EN300-7722227

Suppliers and Price of Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:325.88033
Heavy Atom Count:11
Complexity:121

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)I)CBr

Technology Process of Benzene, 2-(bromomethyl)-1-iodo-4-methoxy-

There total 5 articles about Benzene, 2-(bromomethyl)-1-iodo-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 139557-96-3
(2-iodo-5-methoxyphenyl)methanol

: 293732-24-8
2-(bromomethyl)-1-iodo-4-methoxybenzene

Guidance literature:: With 1H-imidazole; bromine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01927

Reference yield:

: 6971-51-3
3-methoxybenzyl alcohol

: 293732-24-8
2-(bromomethyl)-1-iodo-4-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / I₂; CF₃CO₂Ag / CHCl₃ / 0.5 h / 20 °C

2: 86 percent / PBr₃ / CH₂Cl₂ / 16 h / 20 °C

With iodine; silver trifluoroacetate; phosphorus tribromide; In dichloromethane; chloroform;
DOI:10.1016/j.tet.2004.10.105

Reference yield:

: 54413-93-3
2-iodo-5-methoxybenzoic acid

: 293732-24-8
2-(bromomethyl)-1-iodo-4-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: triphenylphosphine; bromine; 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; borane-THF; bromine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.orglett.8b01927