Chemical Property of Cgp 71683 hydrochloride
Chemical Property:
- Vapor Pressure:1.19E-22mmHg at 25°C
- Boiling Point:747.2°Cat760mmHg
- Flash Point:405.7°C
- Density:g/cm3
- Storage Temp.:Desiccate at +4°C
- Solubility.:H2O: ~14 mg/mL, soluble
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:511.1808741
- Heavy Atom Count:35
- Complexity:751
- Purity/Quality:
-
98%Min *data from raw suppliers
CGP 71683 hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CC(CCC1CNC2=NC3=CC=CC=C3C(=N2)N)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54.Cl
-
Description
CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.
