Carbamic acid, [1-(diethoxyphosphinyl)-1-(trifluoromethyl)-3-butenyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [1-(diethoxyphosphinyl)-1-(trifluoromethyl)-3-butenyl]-, phenylmethyl ester
• CAS No.: 296238-74-9
• Molecular Formula: C17H23F3NO5P
• Molecular Weight: 409.33700
• Mol file: 296238-74-9.mol

Synonyms:(1-BENZYLOXYCARBONYLAMINO-1-TRIFLUOROMETHYL-BUT-3-ENYL)-PHOSPHONIC ACID DIETHYL ESTER;BENZYL N-[4-(DIETHOXYPHOSPHORYL)-5,5,5-TRIFLUOROPENT-1-EN-1-YL]CARBAMATE;

Chemical Property of Carbamic acid, [1-(diethoxyphosphinyl)-1-(trifluoromethyl)-3-butenyl]-, phenylmethyl ester

Chemical Property:

• PSA: 83.67000
• LogP: 5.40450

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [1-(diethoxyphosphinyl)-1-(trifluoromethyl)-3-butenyl]-, phenylmethyl ester

There total 6 articles about Carbamic acid, [1-(diethoxyphosphinyl)-1-(trifluoromethyl)-3-butenyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

{1-[(Z)-Benzyloxycarbonylimino]-2,2,2-trifluoro-ethyl}-phosphonic acid diethyl ester + allylmagnesium bromide (1730-25-2) → 2-(benzyloxycarbonylamino)-2-(diethoxyphosphoryl)-1,1,1-trifluoropent-4-ene (296238-74-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 7h;

Reference yield: 68.0%

{1-[(E)-Benzyloxycarbonylimino]-2,2,2-trifluoro-ethyl}-phosphonic acid diethyl ester + allylmagnesium bromide (1730-25-2) → 2-(benzyloxycarbonylamino)-2-(diethoxyphosphoryl)-1,1,1-trifluoropent-4-ene (296238-74-9)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/1099-0690(200110)2001:20<3891::AID-EJOC3891>3.0.CO;2-R

Reference yield: 62.0%

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate (296238-72-7) + allyl bromide (106-95-6) → 2-(benzyloxycarbonylamino)-2-(diethoxyphosphoryl)-1,1,1-trifluoropent-4-ene (296238-74-9)

Guidance literature:

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate; allyl bromide; With indium; acetic acid; In tetrahydrofuran; at 20 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran;

DOI:10.1080/00397910802431156

upstream raw materials:

allylmagnesium bromide

O-benzyl carbamate

benzyl N-trifluoroacetylcarbamate

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate

Downstream raw materials:

2-[(benzyloxycarbonyl)(prop-2-enyl)amino]-2-(diethoxyphosphoryl)-1,1,1-trifluoropent-4-ene